Anti-Perforin-1 Antibody, clone dG9

61 kDa calculated

Purified granules from the human cytotoxic large granular lymphocytes lymphoma line YT corresponding to human Perforin-1.

Immunoprecipitation Analysis: A representative lot immunoprecipitated Perforin-1 in YT cell lysate with or without Endo H treatment (Uellner, R., et al. (1997). EMBO. 16(24):7287-7296).
Immunocytochemistry Analysis: A representative lot detected Perforin-1 in human lymphokine-activated killer (LAK) cells (Hameed, A., et al. (1992). American J. of Pathology. 140(5):1025-1030).
Immunohistochemistry Analysis: A representative lot detected Perforin-1 in human cardiac biopsy samples during allograft rejection (Hameed, A., et al. (1992). American J. of Pathology. 140(5):1025-1030).

Reacts with non-denatured human perforin precursor and mature perforin, but not denatured perforin.

Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Stable for 1 year at 2-8°C from date of receipt.

Evaluated by Flow Cytometry in human peripheral blood mononuclear cells.

Flow Cytometry Analysis: 3.0 µg of this antibody detected Perforin-1 in human peripheral blood mononuclear cells.

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