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SCC618 MO-91 Acute Myeloid Leukemia w Minimal Differentiation Human Cell Line

Phosphoproteomic analysis has identified the MO-91 human acute myeloid leukemia cell line as a suitable cellular model for the study of TEL-TRKC fusion-associated leukemia, as well as a model of M0 (minimally differentiated) acute myeloid leukemia, or AML.

SCC618
>= 1 x 10^6 cells per vial  
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      Overview

      Replacement Information
      Description
      Catalogue NumberSCC618
      DescriptionMO-91 Acute Myeloid Leukemia w Minimal Differentiation Human Cell Line
      OverviewAcute myeloid leukemia with minimal differentiation (AML-M0) is a rare subtype of leukemia in which myeloid blasts fail to show morphologic differentiation. SCC618, the MO-91 cell line, is the first cell line identified to express the TEL-TRKC fusion gene from its endogenous promoter. It is therefore a valuable cell model for the screening of the TRKC inhibitor and for the study of hematological and non-hematological diseases associated with the TEL-TRKC oncoprotein.

      Note:
      MO-91 is a suspension cell line, but has both suspension and adherent characteristics when growing in tissue culture-treated plasticware lying flat. The monolayer can be dislodged into single cells by pipetting with a 10 mL pipet. No dissociation with Accutase or other reagent is needed. Cells may be cultured in TC-treated flask by placing flask in upright position. Cells at the bottom 1/3 of the upright flask may require more effort to dislodge.
      Alternate Names
      • MO-91 cell line
      • AML cell line
      • Acute myeloid leukemia cell line
      • AML with minimal differentiation cell line
      • M0-91 cell line
      • M0-91 AML cell line
      • MO-91 AML cell line
      Background InformationAML (acute myeloid leukemia) is caused by mutations of the genes involved in hematopoiesis. These mutations result in clonal expansion of myeloid progenitors known as blasts in the bone marrow and peripheral blood. This leads to ineffective erythropoiesis and bone marrow dysfunction. ​
      MO-91 is the first cell line identified to express the TEL-TRKC fusion gene from its endogenous promoter. It is therefore a valuable cell model for the screening of the TRKC inhibitor, and for the study of hematological and non-hematological diseases associated with theTEL-TRKC fusion gene. ​


      SOURCE

      The MO-91 cell line was established from a patient with acute myeloid leukemia with minimal differentiation (AML-M0)



      REFERENCES
      1. Vakiti A, Mewawalla P. Acute Myeloid Leukemia. [Updated 2023 Aug 8]. In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2023 Jan-. Available at https://www.ncbi.nlm.nih.gov/books/NBK507875/

      2. Gu, TL., Popova, L., Reeves, C. et al. Phosphoproteomic analysis identifies the M0-91 cell line as a cellular model for the study of TEL-TRKC fusion-associated leukemia. Leukemia 21, 563–566 (2007). https://doi.org/10.1038/sj.leu.2404555

      3. Venditti, A et al. “Minimally differentiated acute myeloid leukemia (AML-M0): comparison of 25 cases with other French-American-British subtypes.” Blood vol. 89,2 (1997): 621-9.
      References
      Product Information
      Components
      • ≥1x106 viable MO-91 Human Acute Myeloid Leukemia Cells: (Catalog No. SCC618). Store in liquid nitrogen.
      Quality LevelMQ100
      Applications
      ApplicationPhosphoproteomic analysis has identified the MO-91 human acute myeloid leukemia cell line as a suitable cellular model for the study of TEL-TRKC fusion-associated leukemia, as well as a model of M0 (minimally differentiated) acute myeloid leukemia, or AML.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@milliporesigma.com.
      Biological Information
      HostHuman
      Cell Line Type
      • Cancer Cells
      • Leukocyte
      • Blood Cell
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceCells are tested negative for infectious diseases by a Human Essential CLEAR Panel by Charles River Animal Diagnostic Services.
      Cells are verified to be of human origin and negative for inter-species contamination from mouse, rat, Chinese hamster, Golden Syrian hamster, and non-human primate (NHP) as assessed by a Contamination Clear panel by Charles River Animal Diagnostic Services
      Cells are negative for mycoplasma contamination.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsSCC618 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting functionality.
      Packaging Information
      Material Size>= 1 x 10^6 cells per vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC618 04065270972675