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851009 PyBOP

PyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.

PyBOP MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents.
CAS #: 128625-52-5 Molar Mass: 520.39 g/mol Hill Formula: C₁₈H₂₈N₆OP * F₆P
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851009
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Overview

Replacement Information

Key Spec Table

CAS #Hill FormulaMolar Mass
128625-52-5C₁₈H₂₈N₆OP * F₆P520.39 g/mol

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8510090025
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      		 Plastic bottle 25 g
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      8510090100
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          		 Plastic bottle 100 g
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          Description
          Catalogue Number851009
          Replaces01-62-0016
          Brand Family Novabiochem®
          Alternate Names
          • Benzotriazole-1-yl-oxy-tris-pyrrolidino-phosphonium hexafluorophosphate
          Background InformationThe standard in situ coupling reagent for solid phase peptide synthesis [1-5]. This product can replace BOP in all applications without loss of performance. Unlike uronium-based reagents, PyBOP® does not give rise to guanidinated by-products during cyclization and fragment condensation reactions.

          The product number for this product was previously 01-62-0016.

          To obtain a certificate of analysis (CoA) of a lot that begins with the letter "A", please select the option in the right hand menu "Request a COA for Lot#s starting with A".
          References
          Product Information
          CAS number128625-52-5
          Hill FormulaC₁₈H₂₈N₆OP * F₆P
          Molar Mass520.39 g/mol
          HS Code2933 99 80
          Structure formula ImageStructure formula Image
          Quality LevelMQ400
          Applications
          ApplicationPyBOP Novabiochem®. CAS 128625-52-5, molar mass 520.39 g/mol.
          Biological Information
          Physicochemical Information
          Density1.438 g/cm3 (20 °C)
          Melting Point140 - 155 °C
          Vapor pressure<1 hPa (25 °C)
          Dimensions
          Materials Information
          Toxicological Information
          Safety Information according to GHS
          Hazard Pictogram(s) Hazard Pictogram(s)
          Hazard Pictogram(s)
          Hazard Statement(s)H302: Harmful if swallowed.
          H317: May cause an allergic skin reaction.
          H410: Very toxic to aquatic life with long lasting effects.
          Precautionary Statement(s)P261: Avoid breathing dust/ fume/ gas/ mist/ vapours/ spray.
          P264: Wash skin thoroughly after handling.
          P273: Avoid release to the environment.
          P280: Wear protective gloves.
          P301 + P312: IF SWALLOWED: Call a POISON CENTER/doctor if you feel unwell.
          P302 + P352: IF ON SKIN: Wash with plenty of water.
          Signal WordWarning
          Storage class10 - 13 Other liquids and solids
          WGKWGK 3 highly hazardous to water
          Safety Information
          Categories of dangerirritant
          Product Usage Statements
          Storage and Shipping Information
          StorageStore at +2°C to +8°C.
          Packaging Information
          Transport Information
          Declaration (railroad and road) ADR, RIDUN 3077 , 9, III
          Declaration (transport by air) IATA-DGRUN 3077 , 9, III
          Declaration (transport by sea) IMDG-CodeUN 3077 , 9, III, Marine Pollutant: P
          Supplemental Information
          Specifications
          Color (visual)white to slight yellow to beige
          Appearance of substance (visual)powder
          Identity (IR)passes test
          Assay (HPLC, area%)≥ 99.0 % (a/a)
          Solubility (1 mmole in 2 ml DMF)clearly soluble
          Global Trade Item Number
          Catalogue Number GTIN
          8510090025 04027269081089
          8510090100 04027269081096

          Documentation

          PyBOP SDS

          Title

          Safety Data Sheet (SDS) 

          PyBOP Certificates of Analysis

          Product Number PackagingLot Number
          8510090025 Plastic bottle
          8510090100 Plastic bottle

          Brochure

          Title
          Novabiochem Coupling Reagent Flyer 2010
          Novabiochem Innovations 02/06
          Novabiochem Innovations 03/10
          Novabiochem Letters 01/14

          Citations

          Title
          • [1] J. Martinez, et al. (1985) J. Med. Chem., 28, 1874.
          • [2] J. Coste, et al. (1990) Tetrahedron Lett., 31, 205.
          • [3] G. B. Fields, et al. in 'Innovation & Perspectives in Solid Phase Synthesis, 1st International Symposium', R. Epton (Eds), SPCC UK Ltd., Birmingham, 1990, pp. 241.
          • [4] T. Høeg-Jensen, et al. (1991) Tetrahedron Lett., 32, 7617.
          • [5] R. von Eggelkraut-Gottanka, et al. (2003) Tetrahedron Lett., 44, 3551.