Skip to Content
Merck

Key Documents

View All Documentation

A2129

γ-Aminobutyric acid

≥99% (TLC), powder or crystals, inhibitory neurotransmitter

Synonym(s):

GABA, Gammalon, gamma-Aminobutyric acid, 3-Carboxypropylamine, 4-Aminobutanoic acid, Piperidic acid, Piperidinic acid

Sign In to View Organizational & Contract Pricing.

Select a Size

Change View

About This Item

Linear Formula:
NH2(CH2)3COOH
CAS Number:
56-12-2
Molecular Weight:
103.12
NACRES:
NA.32
PubChem Substance ID:
24278167
UNSPSC Code:
12352106
EC Number:
200-258-6
MDL number:
MFCD00008226
Beilstein/REAXYS Number:
906818
Assay:
≥99%
Form:
powder or crystals
Storage condition:
(Tightly closed. Dry.)
Technical Service
Need help? Our team of experienced scientists is here for you.
Let Us Assist

Product Name

γ-Aminobutyric acid, ≥99%

Quality Segment

200

assay

≥99%

form

powder or crystals

storage condition

(Tightly closed. Dry.)

color

colorless

mp

195 °C (dec.) (lit.)

solubility

water: 50 mg/mL, clear, colorless

SMILES string

NCCCC(O)=O

InChI

1S/C4H9NO2/c5-3-1-2-4(6)7/h1-3,5H2,(H,6,7)

InChI key

BTCSSZJGUNDROE-UHFFFAOYSA-N

Gene Information

human ... GABBR1(2550), GABBR2(9568), GABRA1(2554), GABRA2(2555), GABRA3(2556), GABRA4(2557), GABRA5(2558), GABRA6(2559), GABRB1(2560), GABRB2(2561), GABRB3(2562), SLC6A1(6529), SLC6A11(6538), SLC6A12(6539)
rat ... Gabbr1(81657), Gabra1(29705), Gabra2(29706), Gabrb2(25451), Gabrg2(29709), Slc6a1(79212), Slc6a12(50676)

General description

γ-Aminobutyric acid (GABA) is a non-amino protein. It is found in plants, animals, and microorganisms. GABA has been used in pharma and food industries as a component of cheese, shochu, gabaron tea, and gammalone.PMID 24031948
Research area: Neuroscience

Application

γ-Aminobutyric acid (GABA) has been used:
  • in the preparation of GABA–BSA (bovine serum albumin)–GA (glutaraldehyde) conjugate, which is used as a control for GABA immunostainingPMID 9870959
  • in the macromolecule suppressed detection of GABA by magnetic resonance spectroscopy (MRS)PMID 22777748
  • in the intraintestinal application of GABA in order to increase intraluminal fluid secretionPMID 22700823

Biochem/physiol Actions

GABA (γ-Aminobutyric acid) is an amino acid that functions as an inhibitory neurotransmitter in the central nervous system and as a neuromodulator in some peripheral tissues. It binds to the GABAA receptor and inhibits the activity of signal-receiving neurons. The GABAA receptors are found to form a channel in the cell membranes of neurons. Upon binding of GABA, the receptor is activated to allow the passage of negatively charged molecules, such as chloride ions, into the cell. This results in a lowering of the excitability of the cell.PMID 15704348
GABAergic neurons involve myorelaxation, anxiolytic treatment, sedation, and anesthetics. GABA can also influence heart rate and blood pressure.PMID 22162673
GABA improves plasma concentration, growth hormone, and protein synthesis in the brain. It also plays a role in reducing blood pressure in humans. GABA acts as a potent hypotensive, diuretic, and antidiabetic agent. It also regulates serum lipids levels and the sensation of pain.PMID 24031948
PMID 22162673
Major inhibitory neurotransmitter in brain; GABAA and GABAB receptor agonist; increases Cl− conductance.

Other Notes

2024 CiteAb Award Winner for Supplier Succeeding in Parkinson′s Research

Still not finding the right product?

Explore all of our products under γ-Aminobutyric acid

Storage Class

11 - Combustible Solids

wgk

WGK 1

flash_point_f

Not applicable

flash_point_c

Not applicable

ppe

dust mask type N95 (US), Eyeshields, Gloves

Choose from one of the most recent versions:

Certificates of Analysis (COA)

Lot/Batch Number

Don't see the Right Version?

If you require a particular version, you can look up a specific certificate by the Lot or Batch number.

Search for a COA

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library