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Chromolith® HighResolution RP-18 Endcapped Flow Rate

Comparison with Core-Shell Material

Chromolith® HighResolution RP-18e for faster high resolution separations

Compared to core-shell material, the faster flow rates of Chromolith® HighResolution columns considerably reduce analysis time while extending column lifetime. At a flow rate of 1 ml/min, a chromatogram run on a Chromolith® HighResolution HPLC column looks almost identical to the same chromatogram run on a particulate column packed with sub 3 µm particles. Likewise, Chromolith® HighResolution is able to generate similar results as a column packed with 2.6 µm ID core-shell particles, but at much lower back pressures.

Features and Benefits

  • Column performance corresponds to sub 3 µm particle-packed columns and is at least 50% higher compared to standard Chromolith® columns
  • Back pressure at least half that of particulate columns
  • Minimum 30% longer column lifetime compared with particle-packed columns


Chromolith® HighResolution RP-18e
Ordering Number
100 mm 152022
50 mm 152021
25 mm 152020
5 mm Guard Columns (3 pieces) 152025

Chromolith® HighResolution as Alternative to 3 µm Particulate Column

Silica monolithic 
40 bar
100 bar
Silica monolithic 40 bar Core-shell 100 bar
Silica monolithic: 40 bar (Inj. volume) Core-shell: 100 bar (Inj. volume)


Mobile phase A: Acetonitrile
B: 20 mM phosphate buffer pH 4.5
Gradient Time/min %A %B
0.0 20 80
12.0 40 60
Flow rate 1.0 ml/min
Detection UV 254 nm
Temperature 22°C
Inj. volume 2 µl
Sample 1. Ascorbic acid
2. 4-Hydroxybenzoic acid
3. Sorbic acid
5. Methyl 4-hydroxybenzoate
6. Ethyl 4-hydroxybenzonate
7. Propyl 4-hydroxybenzonate
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