Life Science Research
 

MILLIPLEX® Kits for Isotyping Human and Mouse
Immunoglobulins

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Produced by plasma cells and lymphocytes, immunoglobulins (Igs) are crucially involved in immune response, attaching to antigens and playing a role in their destruction. Igs can be classified by isotype, classes that differ in function and antigen response due to structure variability. Five major isotypes are: IgM, IgG, IgA, IgE and IgD – all found in normal individuals. Some autoimmune diseases, GI conditions and malignancies are characterized by specific isotype deficiencies or varying concentrations of one or more isotypes. Disease states can range from the absence of one isotype class or subclass to a total deficiency of Ig classes.

Quantitate Ig classes and subclasses simultaneously with our MILLIPLEX® Isotyping Kits. The xMAP® multiplex technology is ideal for measuring levels of these isotypes, not only decreasing the number of assays as well as the amount of sample required, but also greatly reducing the possible inaccuracies that result from performing multiple assays.

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