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MAB3303 Anti-Collagen Type VI Antibody, clone VI-26

100 µg  
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      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, RbELISA, IH(P)MPurifiedMonoclonal Antibody
      Catalogue NumberMAB3303
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Collagen Type VI Antibody, clone VI-26
      Product Information
      • Testis, connective tissue
      PresentationLiquid in 0.1 M sodium phosphate buffer, pH 7.0, containing 2% protease-free bovine Serum albumin.
      Quality LevelMQ100
      ApplicationAnti-Collagen Type VI Antibody, clone VI-26 detects level of Collagen Type VI & has been published & validated for use in ELISA, IH(P).
      Key Applications
      • ELISA
      • Immunohistochemistry (Paraffin)
      Application NotesImmunohistochemistry on acetone fixed paraffin-embedded tissues. Formalin fixation is not recommended. Antigen recovery is treatment with 0.04% trypsin in 0.01M CaCl(2) 0.05M Tris-HCL pH 7.6, 37°C for 10 minutes before the non-specific peroxidase block.


      Optimal working dilutions must be determined by end user.
      Biological Information
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      SpecificitySpecifically reacts with the hCL(VI). This is a purified mouse monoclonal antibody to human type VI collagen. VI-26 does not react with denatured or reduced type VI collagen, although this antibody does recognize the the triple helix consisting of alpha1(VI), alpha 2(VI) alpha3(gamma). The epitope has not been mapped and the monoclonal is know not to react with collagens I, II, III, IV or V in native assays.
      Species Reactivity
      • Human
      • Rabbit
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes the major type VI alpha collagen chain of basement membranes. Like the other members of the type VI collagen gene family, this gene is organized in a head-to-head conformation with another type VI collagen gene so that each gene pair shares a common promoter.
      Gene Symbol
      • COL6A1
      Non-Reactive Species
      • Rat
      Purification MethodProtein A Purfied
      UniProt Number
      UniProt SummaryFUNCTION: Collagen VI is a major structural component of microfibrils. The basic structural unit of collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains. The alpha2(VI) and alpha3(VI) chains are encoded by the COL6A2 and COL6A3 genes, respectively. Type VI collagen is a unique beaded filament collagen. It is found in the interface between the basement membrane and interstitial matrix, where it forms a unique microfibrillar network. It has several binding partners.
      SIZE: 1028 amino acids; 108,529 Da
      SUBUNIT: Collagen VI is a heterotrimer of the alpha1(VI), alpha2(VI), and alpha3(VI) chains.
      SUBCELLULAR LOCATION: Extracellular matrix.
      TISSUE SPECIFICITY: Expressed in tendon of biceps brachii and many other tissues.
      PTM: Prolines at the third position of the tripeptide repeating unit (G-X-Y) are hydroxylated in some or all of the chains.
      DISEASE: Mutations in COL6A1 gene have been linked to Bethlem myopathy that is characterized by early childhood onset and joint contractures most frequently affecting the elbows and ankles.
      Physicochemical Information
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Availability by Geography
      • This product is not available for sale in Japan.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain for 1 year at -20°C from date of shipment. Aliquot to avoid repeated freezing and thawing. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information


      Anti-Collagen Type VI Antibody, clone VI-26 SDS


      Safety Data Sheet (SDS) 

      Anti-Collagen Type VI Antibody, clone VI-26 Certificates of Analysis

      TitleLot Number
      MOUSE ANTI- HUMAN COLLAGEN TYPE VI - 3436044 3436044
      MOUSE ANTI- HUMAN COLLAGEN TYPE VI - 2073572 2073572
      MOUSE ANTI- HUMAN COLLAGEN TYPE VI - 3172133 3172133
      MOUSE ANTI- HUMAN COLLAGEN TYPE VI - 3286503 3286503
      MOUSE ANTI- HUMAN COLLAGEN TYPE VI - 3540940 3540940
      MOUSE ANTI- HUMAN COLLAGEN TYPE VI - 3731770 3731770
      MOUSE ANTI- HUMAN COLLAGEN TYPE VI - 3759088 3759088
      MOUSE ANTI- HUMAN COLLAGEN TYPE VI -2605423 2605423
      MOUSE ANTI- HUMAN COLLAGEN TYPE VI -2640009 2640009


      Reference overviewPub Med ID
      Recessive COL6A2 C-globular missense mutations in Ullrich congenital muscular dystrophy: role of the C2a splice variant.
      Zhang RZ, Zou Y, Pan TC, Markova D, Fertala A, Hu Y, Squarzoni S, Reed UC, Marie SK, Bönnemann CG, Chu ML
      J Biol Chem  285  10005-15 Epub 2010 Jan 27  2010

      Show Abstract Full Text Article
      20106987 20106987
      Exon skipping mutations in collagen VI are common and are predictive for severity and inheritance.
      A K Lampe,Y Zou,D Sudano,K K O'Brien,D Hicks,S H Laval,R Charlton,C Jimenez-Mallebrera,R-Z Zhang,R S Finkel,G Tennekoon,G Schreiber,M S van der Knaap,H Marks,V Straub,K M Flanigan,M-L Chu,F Muntoni,K M D Bushby,C G Bönnemann
      Human mutation  29  2008

      Show Abstract
      18366090 18366090
      Predominant fiber atrophy and fiber type disproportion in early ullrich disease.
      Joachim Schessl, Nathalie M Goemans, Alexandra I Magold, Yaqun Zou, Ying Hu, Janbernd Kirschner, Raf Sciot, Carsten G Bönnemann
      Muscle nerve  38  1184-91  2008

      Show Abstract
      18720506 18720506
      A new form of congenital muscular dystrophy with joint hyperlaxity maps to 3p23-21.
      Tétreault, M; Duquette, A; Thiffault, I; Bherer, C; Jarry, J; Loisel, L; Banwell, B; D'Anjou, G; Mathieu, J; Robitaille, Y; Vanasse, M; Brais, B
      Brain : a journal of neurology  129  2077-84  2006

      Show Abstract
      16760198 16760198
      Ullrich congenital muscular dystrophy: connective tissue abnormalities in the skin support overlap with Ehlers-Danlos syndromes.
      Janbernd Kirschner, Ingrid Hausser, Yaqun Zou, Gudrun Schreiber, Hans-Jürgen Christen, Susan C Brown, Ingrun Anton-Lamprecht, Francesco Muntoni, Folker Hanefeld, Carsten G Bönnemann
      American journal of medical genetics. Part A  132A  296-301  2005

      Show Abstract
      15690374 15690374
      Collagen VI related muscle disorders.
      Lampe, AK; Bushby, KM
      Journal of medical genetics  42  673-85  2005

      Show Abstract Full Text Article
      16141002 16141002
      Kidneys with heavy proteinuria show fibrosis, inflammation, and oxidative stress, but no tubular phenotypic change.
      Kuusniemi, AM; Lapatto, R; Holmberg, C; Karikoski, R; Rapola, J; Jalanko, H
      Kidney international  68  121-32  2005

      Show Abstract
      15954901 15954901
      Collagen VI status and clinical severity in Ullrich congenital muscular dystrophy: phenotype analysis of 11 families linked to the COL6 loci.
      E Demir, A Ferreiro, P Sabatelli, V Allamand, S Makri, B Echenne, M Maraldi, L Merlini, H Topaloglu, P Guicheney
      Neuropediatrics  35  103-12  2004

      Show Abstract
      15127309 15127309
      Novel COL6A1 splicing mutation in a family affected by mild Bethlem myopathy.
      Olga Camacho Vanegas, Rui-Zhu Zhang, Patrizia Sabatelli, Giovanna Lattanzi, Paola Bencivenga, Betti Giusti, Marta Columbaro, Mon-Li Chu, Luciano Merlini, Guglielmina Pepe
      Muscle nerve  25  513-9  2002

      Show Abstract
      11932968 11932968
      98th ENMC International Workshop on Congenital Muscular Dystrophy (CMD), 7th Workshop of the International Consortium on CMD, 2nd Workshop of the MYO CLUSTER project GENRE. 26-28th October, 2001, Naarden, The Netherlands.
      F Muntoni, E Bertini, C Bönnemann, M Brockington, S Brown, K Bushby, M Fiszman, C Körner, E Mercuri, L Merlini, J Hewitt, S Quijano-Roy, N Romero, S Squarzoni, C A Sewry, V Straub, H Topaloglu, G Haliloglu, T Voit, U Wewer, P Guicheney
      Neuromuscular disorders : NMD  12  889-96  2002

      12398845 12398845

      Data Sheet


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      Life Science Research > Antibodies and Assays > Primary Antibodies