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AB5725 Anti-Gephyrin Antibody

AB5725
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RWBRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB5725
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Gephyrin Antibody
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid.
      Quality LevelMQ100
      Applications
      ApplicationAnti-Gephyrin Antibody is an antibody against Gephyrin for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 0.5-1.0 μg/mL using ECL on mouse cerebellum tissue lysate. The antibody reacts with a protein of ~93 kDa. An additional band of ~35 kDa may also be seen depending on sample used.

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenSynthetic peptide from rat gephyrin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      SpecificityGephyrin
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a neuronal assembly protein that anchors inhibitory neurotransmitter receptors to the postsynaptic cytoskeleton via high affinity binding to a receptor subunit domain and tubulin dimers. In nonneuronal tissues, the encoded protein is also required for molybdenum cofactor biosynthesis. Mutations in this gene may be associated with the neurological condition hyperplexia and also lead to molybdenum cofactor deficiency. Numerous alternatively spliced transcript variants encoding different isoforms have been described; however, the full-length nature of all transcript variants is not currently known.
      Gene Symbol
      • GPHN
      • GPHRYN
      • GPH
      • gephyrin
      • GEPH
      • Gephyrin.
      • KIAA1385
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q9NQX3 # Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Involved in molybdenum cofactor biosynthesis. Required for molybdenum transfer to molybdopterin. In a first step, copper-molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released (By similarity).
      COFACTOR: Magnesium (By similarity).
      SIZE: 736 amino acids; 79748 Da
      SUBUNIT: Homotrimer. Interacts with GABARAP (By similarity).
      DOMAIN:SwissProt: Q9NQX3 Contains 2 functional domains that are expressed as separate proteins in bacteria. The G-domain adenylates molybdopterin. The E-domain inserts molybdenum into adenylated molybdopterin.
      DISEASE: SwissProt: Q9NQX3 # Defects in GPHN are the cause of molybdenum cofactor deficiency type C (MOCOD type C) [MIM:252150]. MOCOD type C is an autosomal recessive disease which leads to the pleiotropic loss of all molybdoenzyme activities and is characterized by severe neurological damage, neonatal seizures and early childhood death.
      SIMILARITY: In the N-terminal section; belongs to the moaB/mog family. & In the C-terminal section; belongs to the moeA family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at +2-8°C in undiluted aliquots for up to 6 months after date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Gephyrin Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Gephyrin Antibody Certificates of Analysis

      TitleLot Number
      RABBIT ANTI-GEPHYRIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2430531 2430531
      RABBIT ANTI-GEPHYRIN - 3245136 3245136
      RABBIT ANTI-GEPHYRIN -2506435 2506435
      RABBIT ANTI-GEPHYRIN AFFINITY PURIFIED - 3451440 3451440
      RABBIT ANTI-GEPHYRIN AFFINITY PURIFIED POLYCLONAL ANTIBODY 2967222
      RABBIT ANTI-GEPHYRIN AFFINITY PURIFIED POLYCLONAL ANTIBODY 2899923
      RABBIT ANTI-GEPHYRIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2198949 2198949
      RABBIT ANTI-GEPHYRIN AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2361817 2361817

      References

      Reference overviewPub Med ID
      Climbing fiber-evoked Purkinje cell discharge reduces expression of GABA(A) receptor-associated protein and decreases its interaction with GABA(A) receptors.
      Qian, Zuyuan, et al.
      J. Neurochem., 117: 197-208 (2011)  2011

      Show Abstract
      21105873 21105873
      Neuroligin 2 is exclusively localized to inhibitory synapses
      Varoqueaux, F. et al.
      Eur J Cell Biol., 83(9):449-456 (2004)  2004

      15540461 15540461