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AB3521 Anti-Leptin Antibody

AB3521
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      M, RELISA, WBChAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberAB3521
      ReplacesMAB3870
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-Leptin Antibody
      References
      Product Information
      FormatAffinity Purified
      PresentationAffinity purified immunoglobulin. Liquid in PBS containing 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationDetect Leptin using this Anti-Leptin Antibody validated for use in ELISA & WB.
      Key Applications
      • ELISA
      • Western Blotting
      Application NotesImmunoblotting: 1:1,000-1:5,000

      ELISA: 1:1,000-1:5,000

      Optimal working dilutions must be determined by the end user.
      Biological Information
      ImmunogenRecombinant rat leptin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostChicken
      SpecificityLeptin, rat and mouse.
      Species Reactivity
      • Mouse
      • Rat
      Antibody TypePolyclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryThis gene encodes a protein that is secreted by white adipocytes, and which plays a major role in the regulation of body weight. This protein, which acts through the leptin receptor, functions as part of a signaling pathway that can inhibit food intake and/or regulate energy expenditure to maintain constancy of the adipose mass. This protein also has several endocrine functions, and is involved in the regulation of immune and inflammatory responses, hematopoiesis, angiogenesis and wound healing. Mutations in this gene and/or its regulatory regions cause severe obesity, and morbid obesity with hypogonadism. This gene has also been linked to type 2 diabetes mellitus development.
      Gene Symbol
      • LEP
      • leptin
      • OB
      • obesity
      • OBS
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: P41159 # May function as part of a signaling pathway that acts to regulate the size of the body fat depot. An increase in the level of LEP may act directly or indirectly on the CNS to inhibit food intake and/or regulate energy expenditure as part of a homeostatic mechanism to maintain constancy of the adipose mass.
      SIZE: 167 amino acids; 18641 Da
      SUBUNIT: Interacts with SIGLEC6.
      SUBCELLULAR LOCATION: Secreted.
      DISEASE:SwissProt: P41159 # Defects in LEP may be a cause of autosomal recessive obesity [MIM:601665].
      SIMILARITY: SwissProt: P41159 ## Belongs to the leptin family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-Leptin Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-Leptin Antibody Certificates of Analysis

      TitleLot Number
      CHICKEN ANTI-LEPTIN, RAT/MOUSE - 3384860 3384860
      CHICKEN ANTI-LEPTIN, RAT/MOUSE -2703729 2703729
      CHICKEN ANTI-LEPTIN, RAT/MOUSE AFFINITY PURIFIED POLYCLONAL ANTIBODY 2967777
      CHICKEN ANTI-LEPTIN, RAT/MOUSE AFFINITY PURIFIED POLYCLONAL ANTIBODY 3053456
      CHICKEN ANTI-LEPTIN, RAT/MOUSE AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2231585 2231585
      CHICKEN ANTI-LEPTIN, RAT/MOUSE AFFINITY PURIFIED POLYCLONAL ANTIBODY - 2376662 2376662