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MAB5574 Anti-NMDAR2B Antibody

MAB5574
100 µL  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      RWBMAscitesMonoclonal Antibody
      Description
      Catalogue NumberMAB5574
      Brand Family Chemicon®
      Trade Name
      • Chemicon
      DescriptionAnti-NMDAR2B Antibody
      References
      Product Information
      FormatAscites
      Control
      • Rat forebrain or cerebellum.
      PresentationLiquid
      Quality LevelMQ100
      Applications
      ApplicationDetect NMDAR2B using this Anti-NMDAR2B Antibody validated for use in WB.
      Key Applications
      • Western Blotting
      Application NotesWestern blot: 1:1,000-1:5,000 on rat brain lysate.

      Optimal working dilutions must be determined by end user.
      Biological Information
      ImmunogenRecombinant protein from rat NMDAR2B.
      Clone1B3.3B6
      HostMouse
      SpecificityNMDAR2B, C-terminal. By Western blot the antibody reacts with bands at ~170 and ~90 kDa on rat brain lysate.
      IsotypeIgG1
      Species Reactivity
      • Rat
      Antibody TypeMonoclonal Antibody
      Entrez Gene Number
      Entrez Gene SummaryN-methyl-D-aspartate (NMDA) receptors are a class of ionotropic glutamate receptors. NMDA receptor channel has been shown to be involved in long-term potentiation, an activity-dependent increase in the efficiency of synaptic transmission thought to underlie certain kinds of memory and learning. NMDA receptor channels are heteromers composed of three different subunits: NR1 (GRIN1), NR2 (GRIN2A, GRIN2B, GRIN2C, or GRIN2D) and NR3 (GRIN3A or GRIN3B). The NR2 subunit acts as the agonist binding site for glutamate. This receptor is the predominant excitatory neurotransmitter receptor in the mammalian brain.
      Gene Symbol
      • GRIN2B
      • MGC142180
      • Glutamate
      • NMDAR2B
      • NR3
      • NR2B
      • MGC142178
      • hNR3
      UniProt Number
      UniProt SummaryFUNCTION: SwissProt: Q13224 # NMDA receptor subtype of glutamate-gated ion channels with high calcium permeability and voltage-dependent sensitivity to magnesium. Mediated by glycine.
      SIZE: 1484 amino acids; 166367 Da
      SUBUNIT: Forms heteromeric channel of a zeta subunit (GRIN1), a epsilon subunit (GRIN2A, GRIN2B, GRIN2C or GRIN2D) and a third subunit (GRIN3A or GRIN3B). Found in a complex with GRIN1 and GRIN3B. Found in a complex with GRIN1, GRIN3A and PPP2CB. Interacts with PDZ domains of INADL and DLG4 (By similarity).
      SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein.
      TISSUE SPECIFICITY: Primarily found in the fronto-parieto-temporal cortex and hippocampus pyramidal cells, lower expression in the basal ganglia.
      SIMILARITY: SwissProt: Q13224 ## Belongs to the glutamate-gated ion channel (TC 1.A.10) family.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMaintain at -20°C in undiluted aliquots for up to 6 months after date of receipt. Avoid repeated freeze/thaw cycles.
      Packaging Information
      Material Size100 µL
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Anti-NMDAR2B Antibody SDS

      Title

      Safety Data Sheet (SDS) 

      Anti-NMDAR2B Antibody Certificates of Analysis

      TitleLot Number
      MOUSE ANTI-NMDAR2B, C-TERMINAL -2784038 2784038
      MOUSE ANTI-NMDAR2B, C-TERMINAL MONOCLONAL ANTIBODY 3049388
      MOUSE ANTI-NMDAR2B, C-TERMINAL MONOCLONAL ANTIBODY - 2469382 2469382
      MOUSE ANTI-NMDAR2B, C-TERMINAL MONOCLONAL ANTIBODY - 2165832 2165832
      MOUSE ANTI-NMDAR2B, C-TERMINAL MONOCLONAL ANTIBODY - 2273820 2273820

      References

      Reference overviewPub Med ID
      Long-term consequences of a prolonged febrile seizure in a dual pathology model.
      Gibbs S, Chattopadhyaya B, Desgent S, Awad PN, Clerk-Lamalice O, Levesque M, Vianna RM, Rébillard RM, Delsemme AA, Hébert D, Tremblay L, Lepage M, Descarries L, Di Cristo G, Carmant L
      Neurobiol Dis  2011

      Show Abstract
      21406232 21406232
      Nickel modulates the electrical activity of cultured cortical neurons through a specific effect on N-methyl-D-aspartate receptor channels.
      P Gavazzo,M Tedesco,M Chiappalone,I Zanardi,C Marchetti
      Neuroscience  177  2011

      Show Abstract
      21182900 21182900
      N-methyl-d-aspartate, hyperpolarization-activated cation current (I) and gamma-aminobutyric acid conductances govern the risk of epileptogenesis following febrile seizures in rat hippocampus.
      Ouardouz M, Lema P, Awad PN, Di Cristo G, Carmant L
      The European journal of neuroscience  31  1252-60. Epub 2010 Mar 22.  2010

      Show Abstract
      20345922 20345922

      Brochure

      Title
      Pathways and Biomarkers of Glutamatergic Synapse Flyer

      Data Sheet

      Title
      MOUSE ANTI-NMDAR2B, C-TERMINAL

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      Categories

      Life Science Research > Antibodies and Assays > Primary Antibodies