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ABN304 Anti-Precerebellin Antibody

ABN304
100 µg  
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      Overview

      Replacement Information

      Key Spec Table

      Species ReactivityKey ApplicationsHostFormatAntibody Type
      H, MWB, IHCRbAffinity PurifiedPolyclonal Antibody
      Description
      Catalogue NumberABN304
      DescriptionAnti-Precerebellin Antibody
      Alternate Names
      • Cerebellin precursor
      • Cerebellin
      • CER
      • Precerebellin
      Background InformationPrecerebellin is the precursor of the brain-specific hexadecapeptide cerebellin, a protein with substantial similarity to the globular region of the B chain of complement component C1q. Cerebellin exerts neuromodulatory functions by directly stimulating norepinephrine release via the adenylate cyclase/pka-dependent signaling pathway; and indirectly enhances adrenocortical secretion in vivo, through a paracrine mechanism involving medullary catecholamine release. The active form of precerebellin is highly enriched in postsynaptic structures of cerebellar Purkinje cells in cartwheel neurons of the dorsal cochlear nucleus. Because precerebellin belongs to the C1q/tumor necrosis factor superfamily of secreted proteins and has similarity to adiponectin and CTRP3, it has been suggested that precerebellin possess functions other than those already stated.
      References
      Product Information
      FormatAffinity Purified
      Control
      • Mouse cerebellum tissue lysate
      PresentationPurified rabbit polyclonal in buffer containing PBS with 0.02% sodium azide.
      Quality LevelMQ100
      Applications
      ApplicationThis Precerebellin antibody is validated for use in WB & IHC for the detection of the Precerebellin protein.
      Key Applications
      • Western Blotting
      • Immunohistochemistry
      Application NotesImmunohistochemistry Analysis: A 1:2,000 dilution from a representative lot detected Precerebellin in human cerebellum tissue.
      Biological Information
      ImmunogenKLH-conjugated linear peptide corresponding to human Precerebellin.
      ConcentrationPlease refer to the Certificate of Analysis for the lot-specific concentration.
      HostRabbit
      Species Reactivity
      • Human
      • Mouse
      Antibody TypePolyclonal Antibody
      Gene Symbol
      • CBLN1
      Purification MethodAntigen Affinity Purified
      UniProt Number
      Molecular Weight~35 kDa observed. The calculated molecular weight is 22 kDa, however, the full length Precerebellin has been shown as a ~35 kDa band. (Bao, D., et al. (2005). Journal of Neurochemistry. 95:618-629.) An uncharacterized band may appear at ~50 kDa in some lysates.
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality AssuranceEvaluated by Western Blot in mouse cerebellum lysate.

      Western Blot Analysis: 1 µg/mL of this antibody detected Precerebellin in 10 µg/mL of mouse cerebellum tissue lysate.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsStable for 1 year at 2-8°C from date of receipt.
      Packaging Information
      Material Size100 µg
      Transport Information
      Supplemental Information
      Specifications