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218200 Cardiotrophin-1, Human, Recombinant, E. coli

218200
  
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      Overview

      Replacement Information
      Description
      Overview

      This product has been discontinued.





      Recombinant, human cardiotrophin-1 expressed in E. coli. A cytokine with structural similarities to interleukin-6. Promotes the survival of neonatal cardiomyocytes via the activation of an anti-apoptotic signaling pathway requiring MAP kinases. Induces a distinct hypertrophic response to endothelin-1 in cultured neonatal cardiomyocytes. Also induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli.
      Catalogue Number218200
      Brand Family Calbiochem®
      SynonymsrhCT-1
      References
      ReferencesChandrasekar, B., et al. 1998. Immunol. Lett. 61, 89.
      Kuwahara, K., et al. 1998. J. Cardiovasc. Pharmacol. 31, 5354.
      Stephanou, A., et al. 1998. J. Mol. Cell. Cardiol. 30, 849.
      Sheng, Z., et al. 1997. J. Biol. Chem. 272, 5783.
      Product Information
      FormLyophilized
      Applications
      Biological Information
      Biological activityED₅₀: ≤1 ng/ml as measured by the ability of CT-1 to induce proliferation of TF-1 cells in a dose-dependent manner
      Purity≥99% by HPLC; ≥99% by SDS-PAGE
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cardiotrophin-1, Human, Recombinant, E. coli Certificates of Analysis

      TitleLot Number
      218200

      References

      Reference overview
      Chandrasekar, B., et al. 1998. Immunol. Lett. 61, 89.
      Kuwahara, K., et al. 1998. J. Cardiovasc. Pharmacol. 31, 5354.
      Stephanou, A., et al. 1998. J. Mol. Cell. Cardiol. 30, 849.
      Sheng, Z., et al. 1997. J. Biol. Chem. 272, 5783.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision03-June-2008 RFH
      SynonymsrhCT-1
      DescriptionRecombinant, human cardiotrophin-1 expressed in E. coli. A cytokine with structural similarities to interleukin-6. Promotes the survival of neonatal cardiomyocytes via the activation of an anti-apoptotic signaling pathway requiring MAP kinases. Induces a distinct hypertrophic response to endothelin-1 in cultured neonatal cardiomyocytes. Also induces heat shock protein accumulation in cultured cardiac cells and protects them from stressful stimuli.
      FormLyophilized
      Purity≥99% by HPLC; ≥99% by SDS-PAGE
      Biological activityED₅₀: ≤1 ng/ml as measured by the ability of CT-1 to induce proliferation of TF-1 cells in a dose-dependent manner
      SolubilityReconstitute in 100 µl H₂O. For more diluted concentrations, add a stabilizing protein such as BSA (100 µg/ml).
      Storage -20°C
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesChandrasekar, B., et al. 1998. Immunol. Lett. 61, 89.
      Kuwahara, K., et al. 1998. J. Cardiovasc. Pharmacol. 31, 5354.
      Stephanou, A., et al. 1998. J. Mol. Cell. Cardiol. 30, 849.
      Sheng, Z., et al. 1997. J. Biol. Chem. 272, 5783.