219013 Caspase-3 Inhibitor VIII

219013
  
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      Overview

      Replacement Information

      Key Spec Table

      Empirical Formula
      C₁₈H₂₄N₂O₆
      Description
      Overview

      This product has been discontinued.





      A cell-permeable dipeptidyl aspartic aldehyde that potently inhibits caspase-3 activity (Ki0 = 3.6 nM) in a reversible and substrate-competitive manner. Z-tLeu-Asp-H, at a concentration of ≥0.43 nM, is shown to completely inhibit the vitamine E-induced PARP cleavage in human DLD-1 colon adenocarcinoma cells, while the activation of caspase-3 by its upstream caspases is not affected.
      Catalogue Number219013
      Brand Family Calbiochem®
      SynonymsN-Benzyloxycarbonyl-(S)-tert-butyl-Leu-Asp-Aldehyde, Z-tLD-CHO
      References
      ReferencesColantonio, P., et al. 2008. Biochem. Biophys. Res. Commun. 377, 757.
      Product Information
      FormLyophilized solid
      Hill FormulaC₁₈H₂₄N₂O₆
      Chemical formulaC₁₈H₂₄N₂O₆
      Applications
      Biological Information
      Purity≥97% by HPLC
      Physicochemical Information
      Peptide SequenceZ-tertLeu-Asp-H
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Protect from Light Protect from light
      Do not freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Packaging Information
      Packaged under inert gas Packaged under inert gas
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Caspase-3 Inhibitor VIII SDS

      Title

      Safety Data Sheet (SDS) 

      Caspase-3 Inhibitor VIII Certificates of Analysis

      TitleLot Number
      219013

      References

      Reference overview
      Colantonio, P., et al. 2008. Biochem. Biophys. Res. Commun. 377, 757.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-June-2009 JLN
      SynonymsN-Benzyloxycarbonyl-(S)-tert-butyl-Leu-Asp-Aldehyde, Z-tLD-CHO
      DescriptionA cell-permeable dipeptidyl aspartic aldehyde that potently inhibits caspase-3 activity (Ki0 = 3.6 nM) in a reversible and substrate-competitive manner. Z-tLeu-Asp-H, at a concentration of ≥0.43 nM, is shown to completely inhibit the vitamine E-induced PARP cleavage in human DLD-1 colon adenocarcinoma cells, while the activation of caspase-3 by its upstream caspases is not affected.
      FormLyophilized solid
      Intert gas (Yes/No) Packaged under inert gas
      Chemical formulaC₁₈H₂₄N₂O₆
      Peptide SequenceZ-tertLeu-Asp-H
      Purity≥97% by HPLC
      SolubilityDMSO (5 mg/ml). Fresh, anhydrous DMSO is recommended.
      Storage -20°C
      Protect from light
      Do Not Freeze Ok to freeze
      Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
      Toxicity Standard Handling
      ReferencesColantonio, P., et al. 2008. Biochem. Biophys. Res. Commun. 377, 757.