219428 Cyclin-Dependent Protein Kinase Inhibitor Set - Calbiochem

219428
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219428-1SET
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      Description
      OverviewContains 5 mg of Olomoucine (Cat. No. 495620), 1 mg of Iso-Olomoucine (Cat. No. 495622), and 1 mg of Roscovitine (Cat. No. 557360). Supplied with an informational insert.
      Catalogue Number219428
      Brand Family Calbiochem®
      References
      ReferencesMeijer, L. 1996. Trends in Cell Biol. 6, 393.
      Glab, N., et al. 1994. FEBS Lett. 353, 207.
      Vesely, J., et al. 1994. Eur. J. Biochem. 224, 771.
      Product Information
      FormSolid
      Quality LevelMQ100
      Applications
      Biological Information
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Storage and Shipping Information
      Ship Code Ambient Temperature Only
      Toxicity Standard Handling
      Storage -20°C
      Do not freeze Ok to freeze
      Packaging Information
      Transport Information
      Supplemental Information
      Specifications

      Documentation

      Cyclin-Dependent Protein Kinase Inhibitor Set - Calbiochem SDS

      Title

      Safety Data Sheet (SDS) 

      Cyclin-Dependent Protein Kinase Inhibitor Set - Calbiochem Certificates of Analysis

      TitleLot Number
      219428

      References

      Reference overview
      Meijer, L. 1996. Trends in Cell Biol. 6, 393.
      Glab, N., et al. 1994. FEBS Lett. 353, 207.
      Vesely, J., et al. 1994. Eur. J. Biochem. 224, 771.
      Data Sheet

      Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

      Revision05-June-2008 RFH
      DescriptionThe eight cyclin-dependent protein kinases (Cdks) that have been identified to date play an essential role in the regulation of the cell cycle. Each Cdk is thought to be regulated by its transient association with one or more members of the cyclin family. These Cdk/cyclin complexes reportedly regulate each step of the cell cycle. For example, the G1/S transition is regulated by Cdk2/cyclin E, Cdk3/unknown cyclin, Cdk4/cyclin D1-3, Cdk6/cyclin D1, and Cdk8/cyclin C. The frequent deregulation of Cdks and their regulators in cancer has stimulated the search for potent and selective inhibitors of Cdks for both research and therapeutic use. Calbiochem® brand offers a set of two such inhibitors and a negative control compound. All three compounds are cell-permeable and act by competitively binding to the ATP binding site of the kinases.
      FormSolid
      Storage -20°C
      Do Not Freeze Ok to freeze
      Toxicity Standard Handling
      ReferencesMeijer, L. 1996. Trends in Cell Biol. 6, 393.
      Glab, N., et al. 1994. FEBS Lett. 353, 207.
      Vesely, J., et al. 1994. Eur. J. Biochem. 224, 771.