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SCC101 MCF-7/TAMR-1 Human Breast Cancer Cell Line

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SCC101
≥1X10⁶ cells/vial  
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      Overview

      Replacement Information

      Key Spec Table

      Key Applications
      CULT
      Description
      Catalogue NumberSCC101
      DescriptionMCF-7/TAMR-1 Human Breast Cancer Cell Line
      Alternate Names
      • MCF7 TAMR-1
        Human breast cancer cell line
        Tamoxifen resistant breast cancer cell line
      Background InformationEstrogen receptor-positive breast cancer is the most common type of breast cancer. About 80% of all breast cancers express the estrogen receptor (ER+) and depend on estrogen to support the growth and spread of the cancer cells. Hormonal therapy, such as tamoxifen, may help slow or stop the growth of ER+ breast cancers by blocking the actions of estrogen. Primary or acquired tamoxifen resistance poses a major clinical challenge in the treatment of ER+ breast cancer. The MCF-7/TAMR-1 cell line provides a model cell system for studying tamoxifen resistance, elucidating signaling pathways involved in tamoxifen-resistant growth, and identifying new predictive markers for response to hormonal therapy.

      MCF-7/TAMR-1 is a tamoxifen-resistant cell line derived from the MCF-7/SO.5 cell line that has been adapted to grow at low serum concentration under the long-term treatment with 1 µM with tamoxifen. MCF-7/TAMR-1 cells should be maintained in 1 µM tamoxifen and may be compared with the parental MCF-7/S0.5 cells, which are sensitive to tamoxifen.

      References:
      1. Briand, P., and Lykkesfeldt, A.E. (1984) Effect of estrogen and antiestrogen on the human breast cancer cell line MCF-7 adapted to growth at low serum concentrations. Cancer Res. 44(3): 1114-1119.
      2. Lykkesfeldt, A.E., and Briand, P. (1986) Indirect mechanism of oestradiol stimulation of cell proliferation of human breast cancer cell lines. Br. J. Cancer 53(1): 29-35.
      3. Madsen, M.W., Reiter, B.E., Lykkesfeldt, A.E. (1995) Differential expression of estrogen receptor mRNA splice variants in the tamoxifen resistant human breast cancer cell line, MCF-7/TAMR-1 compared to the parental MCF-7 cell line. Mol. Cell Endocrinol. 109(2): 197-207.
      References
      Product Information
      HS Code3002 90 99
      Quality LevelMQ100
      Applications
      ApplicationMCF-7/TAMR-1 is a tamoxifen-resistant cell line derived from the MCF-7/S0.5 human breast cancer cell line by long term treatment with the drug tamoxifen.
      Key Applications
      • Cell Culture
      Application NotesThis product is intended for sale and sold solely to academic institutions for internal academic research use per the terms of the “Academic Use Agreement” as detailed in the product documentation. For information regarding any other use, please contact licensing@emdmillipore.com.
      Biological Information
      ConcentrationPlease refer to lot specific datasheet.
      Cell Line Type
      • Cancer Cells
      Physicochemical Information
      Dimensions
      Materials Information
      Toxicological Information
      Safety Information according to GHS
      Safety Information
      Product Usage Statements
      Quality Assurance• Each vial contains ≥ 1X106 viable cells.
      • Cells are tested by PCR and are negative for HPV-16, HPV-18, Hepatitis A, B, C and HIV-1 & 2 viruses.
      • Cells are negative for mycoplasma contamination.
      • Each lot of cells are genotyped by STR analysis to verify the unique identity of the cell line.
      Usage Statement
      • Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
      Storage and Shipping Information
      Storage ConditionsMCF-7/TAMR-1 cells should be stored in liquid nitrogen. The cells can be cultured for at least 10 passages after initial thawing without significantly affecting the cell marker expression and functionality.
      Packaging Information
      Material Size≥1X10⁶ cells/vial
      Transport Information
      Supplemental Information
      Specifications
      Global Trade Item Number
      Catalogue Number GTIN
      SCC101 04054839075797