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385581 11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem

385581
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Panoramica

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Tabella delle specifiche principali

Empirical FormulaCAS #
C₂₆H₃₃BrN₂O₃ 1009373-58-3

Products

Numero di catalogoConfezionamento Qtà/conf
385581-10MG 10 mg
Description
OverviewA cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10mg/kg in animals p.o.) results in an ˜ 80% reduction in the concentration of plasma cortisol over vehicle treated controls.
Catalogue Number385581
Brand Family Calbiochem®
References
ReferencesTice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.
Product Information
CAS number1009373-58-3
FormWhite solid
Hill FormulaC₂₆H₃₃BrN₂O₃
Chemical formulaC₂₆H₃₃BrN₂O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

11beta-HSD1 Inhibitor, 10j - CAS 1009373-58-3 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
385581

Riferimenti bibliografici

Panoramica delle referenze
Tice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
DescriptionA cell permeable, spirocyclic urea that acts as a selective inhibitor of 11β-hydroxysteroid dehydrogenase 1 (11β-HSD1) (IC50 of 1.6 nM and 5.3 nM) in enzyme and human adipocyte assays, respectively. Consisting of 2 enantiomers, 10j2 (R Isomer) is shown to be ˜ 2-3X more potent than 10j1 (S Isomer), in both aforementioned assays. 11β-HSD1 activity in the presence of 10j2 (10 mg/kg in animals p.o.) results in an ~80% reduction in the concentration of plasma cortisol over vehicle treated controls.
FormWhite solid
CAS number1009373-58-3
Chemical formulaC₂₆H₃₃BrN₂O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSL (100 mg/ml)
Storage +2°C to +8°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesTice, C.M., et al. 2009. Bioorg. Med. Chem. Lett. 20, 881.