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100068 17-AAG - CAS 75747-14-7 - Calbiochem

100068
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₃₁H₄₃N₃O₈ 75747-14-7

Products

Numero di catalogoConfezionamento Qtà/conf
100068-500UG Fiala di plastica 500 μg
Description
OverviewA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin, Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Induces apoptosis and displays antitumor effects (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53 (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt and hence inhibits the Ras/Raf/MEK and PI3-kinase signaling pathways. Also sensitizes cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380) and downregulates vascular endothelial growth factor expression.
Catalogue Number100068
Brand Family Calbiochem®
SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
References
ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
Clarke, P.A., et al. 2002. Oncogene 19, 4125.
Clarke, P.A., et al. 2000. Oncogene 19, 4125.
Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
Product Information
CAS number75747-14-7
ATP CompetitiveN
FormPurple solid
Hill FormulaC₃₁H₄₃N₃O₈
Chemical formulaC₃₁H₄₃N₃O₈
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetHsp90
Primary Target IC<sub>50</sub>EC50 = 7.2 µM for Hsp90
Purity≥98% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Blue Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

17-AAG - CAS 75747-14-7 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

17-AAG - CAS 75747-14-7 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
100068

Riferimenti bibliografici

Panoramica delle referenze
Basso, A.D., et al. 2002. Oncogene 21, 1159.
Clarke, P.A., et al. 2002. Oncogene 19, 4125.
Clarke, P.A., et al. 2000. Oncogene 19, 4125.
Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-October-2007 RFH
SynonymsNSC-330507, 17-AG, 17-(Allylamino)-17-demethoxygeldanamycin, 17-Allylaminogeldanamycin
DescriptionA less toxic, potent, synthetic derivative of the ansamycin benzoquinone antibiotic Geldanamycin Streptomyces hygroscopicus (Cat. No. 345805) that binds to Hsp90 (EC50 = 7.2 µM) and regulates its function. Reported to induce apoptosis and exhibit anti-tumor properties (IC50 = 4.1 nM in SKBR3 and 5.2 nM in MCF7 cells). Depletes cancer cells of erbB-1, erbB-2 (EC50 = 45 nM), mutant p53, (EC50 = 62 nM), Raf-1 (EC50 = 80 nM), and Akt. Hence, inhibits the Ras/Raf/MEK and PI3-Kinase signaling pathways. Shown to sensitize cancer cells to Paclitaxel (Cat. No. 580555) and Doxorubicin (Cat. No. 324380), and down-regulates vascular endothelial factor expression.
FormPurple solid
Intert gas (Yes/No) Packaged under inert gas
CAS number75747-14-7
Chemical formulaC₃₁H₄₃N₃O₈
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (10 mg/ml) or Methanol (10 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBasso, A.D., et al. 2002. Oncogene 21, 1159.
Clarke, P.A., et al. 2002. Oncogene 19, 4125.
Clarke, P.A., et al. 2000. Oncogene 19, 4125.
Schulte, T.W., and Neckers, L.M. 1998. Cancer Chemother. Pharmacol. 42, 273.
Schnur, R.C., et al. 1995. J. Med. Chem. 38, 3806.

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Categorie

Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Other Inhibitors of Biological Interest > Heat Shock Protein Inhibitors