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123855 AKR1C3 Inhibitor - Calbiochem

123855
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₄H₁₀F₃NO₂

Products

Numero di catalogoConfezionamento Qtà/conf
123855-25MG Bottiglia di vetro 25 mg
Description
OverviewA cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 60 nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50 µM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10 µM).
Catalogue Number123855
Brand Family Calbiochem®
Synonyms3-(4-(Trifluoromethyl)phenylamino)benzoic acid
References
ReferencesAdeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.
Product Information
FormWhite powder
Hill FormulaC₁₄H₁₀F₃NO₂
Chemical formulaC₁₄H₁₀F₃NO₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

AKR1C3 Inhibitor - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

AKR1C3 Inhibitor - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
123855

Riferimenti bibliografici

Panoramica delle referenze
Adeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-July-2012 JSW
Synonyms3-(4-(Trifluoromethyl)phenylamino)benzoic acid
DescriptionA cell-permeable 3-phenyl-aminobenzoate compound that acts as a potent, competitive, reversible, active-site targeting inhibitor of aldo-keto reductase 1C3 (AKR1C3; type 5 17β-hydroxysteroid dehydrogenase) (IC50 = 60 nM) with excellent selectivity over other closely related human AKR isoforms (IC50 = 22.7, 15.4, 62.7, >50, and >50 µM for and AKR1C1, AKR1C2, AKR1C4, AKR1B1 and AKR1B10, respectively. Exhibits a weak inhibitory effect on cyclooxygenase 1 and 2 (IC50 = 100 µM). Shown to efficiently block the AKR1C3-mediated production of testosterone in LNCaP-AKR1C3 cells (~10 µM).
FormWhite powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₁₀F₃NO₂
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesAdeniji, A.O., et al. 2012. J. Med. Chem. 55, 2311.
Adeniji, A.O., et al. 2011. Bioorg. Med. Chem. Lett. 21,1464.