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171263 AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem

171263
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₁₈H₁₉N₃O₃S 280112-24-5

Products

Numero di catalogoConfezionamento Qtà/conf
171263-5MG Bottiglia di vetro 5 mg
Description
OverviewA cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~ 0.1 µM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 µM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No. 171260).
Catalogue Number171263
Brand Family Calbiochem®
Synonyms4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
Application Data
References
ReferencesLemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.
Product Information
CAS number280112-24-5
FormOff-white solid
Hill FormulaC₁₈H₁₉N₃O₃S
Chemical formulaC₁₈H₁₉N₃O₃S
Quality LevelMQ100
Applications
ApplicationThe AMPK Signaling Agonist, F17, also referenced under CAS 280112-24-5, controls the biological activity of AMPK. This AMPK activator and small molecule/inhibitor is primarily used for Biochemicals applications.
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

AMPK Signaling Activator IX, F17 - CAS 280112-24-5 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
171263

Riferimenti bibliografici

Panoramica delle referenze
Lemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision30-April-2012 JSW
Synonyms4-hydroxy-1-isobutyl-N-(5-methylthiazol-2-yl)-2-oxo-1,2-dihydroquinoline-3-carboxamide
Application Data
DescriptionA cell-permeable 4-hydroxy-2-oxo quinoline carboxamide that acts as an agonist of AMPK signaling. It is shown to reduce fat storage in C. elegans (EC50 ~ 0.1 µM) and reduce the expression level of fat-7 (a C. elegans ortholog of mammalian stearoyl-CoA desaturase-1), through aak-1 (an ortholog for the AMPK-α1 catalytic subunit) and K08F8.2 (a transcription factor) dependent mechanisms. In addition, it markedly reduces the number of lipid droplets in HepG2 human hepatocarcinoma cells at 25 µM, and elicits the phosphorylation and inactivation of acetyl coenzyme A carboxylase (ACC, the enzyme that catalyzes the rate-limiting step in de novo fatty acid synthesis). F17-induced ACC phosphorylation can be abrogated by simultaneous treatment with an AMPK inhibitor compound C (Cat. No. 171260).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
CAS number280112-24-5
Chemical formulaC₁₈H₁₉N₃O₃S
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml; clear, colorless solution). Warming to 55-60°C is required for complete solubilization.
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesLemieux, G.A., et al. 2011. Nat. Chem. Biol. 7, 206.