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124037 Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem

124037
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₁₀H₈ClNO 28755-03-5

Products

Numero di catalogoConfezionamento Qtà/conf
124037-25MG Bottiglia di vetro 25 mg
Description
OverviewA cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases. Effectively inhibits Akt-mediated downstream effector proteins phosphorylation in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth in mice (EC50 = 30 mg/kg; 5 times/wk for 3 wks via p.o.) in vivo.
Catalogue Number124037
Brand Family Calbiochem®
Synonyms3-Chloroacetyl-indole, 2-Chloro-1-(1H-indol-3-yl)ethanone
References
ReferencesKim, D.J., et al. 2011. Cancer Prev. Res. 4, 1842.
Product Information
CAS number28755-03-5
FormPink solid
Hill FormulaC₁₀H₈ClNO
Chemical formulaC₁₀H₈ClNO
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Akt Inhibitor XIX, 3CAI - CAS 28755-03-5 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
124037

Riferimenti bibliografici

Panoramica delle referenze
Kim, D.J., et al. 2011. Cancer Prev. Res. 4, 1842.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-July-2012 JSW
Synonyms3-Chloroacetyl-indole, 2-Chloro-1-(1H-indol-3-yl)ethanone
DescriptionA cell-permeable chloroacetyl-indole compound that inhibits Akt1 and Akt2 kinase activity (IC50 <1 µM) by directly targeting Akt PH domain, exhibiting little or much reduced activity against a panel of 84 other kinases, including PI-3 Kinase (60% inhibition at 10 µM). Effectively inhibits Akt-mediated cellular GSK3β Ser9 and mTOR Ser2448 phosphorylation (4 µM in HCT116 cultures) in a time-dependent manner, resulting in effective apoptosis induction in HCT116 and HT29 cultures (by 55% and 60%, respectively; 4 µM for 4 days). Reported to retard HCT116-derived tumor growth by 50% when administered at an oral dosage of 30 mg/kg in mice (5 times/wk for 3 wks) in vivo.
FormPink solid
Intert gas (Yes/No) Packaged under inert gas
CAS number28755-03-5
Chemical formulaC₁₀H₈ClNO
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (100 mg/ml)
Storage -20°C
Protect from moisture
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesKim, D.J., et al. 2011. Cancer Prev. Res. 4, 1842.