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124036 Akt Inhibitor XVIII, SC66 - Calbiochem

124036
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₈H₁₆N₂O

Products

Numero di catalogoConfezionamento Qtà/conf
124036-25MG Bottiglia di vetro 25 mg
Description
OverviewA cell-permeable pyridine compound that selectively targets Akt, but not PLCδ, PH domain, preventing Akt membrane localization/activation and rendering Akt in a conformation susceptible to ubiquitination and subsequent proteasomal degradation. Akti-1/2 (Cat. Nos. 124017 & 124018) competes for Akt PH domain binding and blocks SC66-induced Akt ubiquitination and proteasomal degradation. Effectively inhibits HEK293T growth both in vitro (>99 inhibition at 0.4 µM) and in mice in vivo (84% of control tumor size with twice weekly i.p. dose of 30 mg/kg), Synergizes with LY294002 (Cat. Nos. 440202 & 440204) in cell death induction in HeLa and HS-Sultan cultures in vitro.
Catalogue Number124036
Brand Family Calbiochem®
Synonyms(2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone
References
ReferencesJo, H., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 6486.
Product Information
CAS number871361-88-5
FormPale yellow solid
Hill FormulaC₁₈H₁₆N₂O
Chemical formulaC₁₈H₁₆N₂O
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Akt Inhibitor XVIII, SC66 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Riferimenti bibliografici

Panoramica delle referenze
Jo, H., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 6486.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-April-2012 JSW
Synonyms(2E,6E)-2,6-bis(4-Pyridylmethylene)cyclohexanone
DescriptionA cell-permeable pyridine compound that represses Akt activation by allosterically disrupting Akt-PH domain binding to PIP3 and directly facilitating Akt ubiquitination with little proteasomal or deubiquitination activity. Blocks phosphorylations of Akt-Ser473 and downstream targets TSC, FOXO and PRAS40 in HEK293T cells at 8 µg/ml with minimal effect on pAkt-Thr450. Shown to be highly efficacious towards PI 3-K inhibitor resistant Akt1-E17K mutant and exert synergistic apoptotic activity with LY 294002 (Cat. No. 440202) against HeLa cells. Suppresses tumor growth in a mouse HEK293T-xenograft model (30 mg/kg, s.c., twice per week).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number871361-88-5
Chemical formulaC₁₈H₁₆N₂O
Structure formulaStructure formula
Purity≥98% by HPLC
SolubilityDMSO (25 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Regulatory Review
ReferencesJo, H., et al. 2011. Proc. Natl. Acad. Sci. USA 108, 6486.