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407286 Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6)

407286
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Species ReactivityHostAntibody Type
H M Monoclonal Antibody

Products

Numero di catalogoConfezionamento Qtà/conf
407286-100UG Fiala di plastica 100 μg
Description
OverviewRecognizes the αv integrin chain and all αv-containing integrins.
Catalogue Number407286
Brand Family Calbiochem®
SynonymsAnti-CD51
References
ReferencesAkiyama, S.K. 1996. Hum. Cell 9, 181.
Hynes, R.O. 1992. Cell 69, 11.
Albelda, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol. 3, 179.
Hynes, R.O. 1987. Cell 45, 549.
Product Information
FormLiquid
FormulationIn PBS, pH 7.6.
Preservative≤0.1% sodium azide
Quality LevelMQ100
Applications
Application ReferencesCell Inhibition Assays, ELISA, Flow Cytometry, and Immunoprecipitation Mitjans, F., et al. 1995 J. Cell Sci. 108, 2825.
Key Applications Immunoprecipitation
Cell Inhibition Assays
Enzyme-Linked Immunosorbent Assay
Flow Cytometry
Application NotesCell Inhibition Assays (see application reference)
ELISA (see application reference)
Flow Cytometry (2.5 µg/ml, see application reference)
Immunoprecipitation (2.5 µg/ml, see application reference)
Application CommentsCross-reacts with all αv integrins. Blocks cell adhesion mediated by all αv integrins and in vivo melanoma growth and angiogenesis (see application references). Variables associated with assay conditions will dictate the proper working dilution.
Biological Information
Immunogenhuman placental αvβ₃ integrin
ImmunogenHuman
Clone272-17E6
HostMouse
IsotypeIgG₁
Species Reactivity
  • Human
Antibody TypeMonoclonal Antibody
Concentration Label Please refer to vial label for lot-specific concentration
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage -20°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6) MSDS

Titolo

Scheda di sicurezza (MSDS) 

Anti-Integrin αv (Ab-1) Mouse mAb (272-17E6) Certificati d'Analisi

TitoloNumero di lotto
407286

Riferimenti bibliografici

Panoramica delle referenze
Akiyama, S.K. 1996. Hum. Cell 9, 181.
Hynes, R.O. 1992. Cell 69, 11.
Albelda, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol. 3, 179.
Hynes, R.O. 1987. Cell 45, 549.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision16-April-2012 JSW
SynonymsAnti-CD51
ApplicationCell Inhibition Assays (see application reference)
ELISA (see application reference)
Flow Cytometry (2.5 µg/ml, see application reference)
Immunoprecipitation (2.5 µg/ml, see application reference)
DescriptionPurified mouse monoclonal antibody. Recognizes the αv integrin chain and all αv-containing integrins.
BackgroundThe integrins are a family of more than 23 heterodimeric transmembrane proteins that mediate cell-cell adhesions as well as cell-substratum adhesions and signal transduction processes. Integrins are heterodimers consisting of noncovalently associated α and β subunits. Human CD51 is an integrin alpha v chain which can associate with five different beta chains (β1, β3, β5, β6, and β8) to form various adhesion molecules. CD51 is found in endothelial cells, smooth muscle cells, fibroblasts, mast cells, monocytes, osteoclasts, platelets, and melanoma cells.
HostMouse
Immunogen speciesHuman
Immunogenhuman placental αvβ₃ integrin
Clone272-17E6
IsotypeIgG₁
Specieshuman
FormLiquid
FormulationIn PBS, pH 7.6.
Concentration Label Please refer to vial label for lot-specific concentration
Preservative≤0.1% sodium azide
CommentsCross-reacts with all αv integrins. Blocks cell adhesion mediated by all αv integrins and in vivo melanoma growth and angiogenesis (see application references). Variables associated with assay conditions will dictate the proper working dilution.
Storage -20°C
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-20°C).
Toxicity Standard Handling
ReferencesAkiyama, S.K. 1996. Hum. Cell 9, 181.
Hynes, R.O. 1992. Cell 69, 11.
Albelda, S.M. and Buck, C.A. 1990. FASEB J. 4, 2868.
Buck, C.A. and Horwitz, A.F. 1987. Ann. Rev. Cell Biol. 3, 179.
Hynes, R.O. 1987. Cell 45, 549.
Application referencesCell Inhibition Assays, ELISA, Flow Cytometry, and Immunoprecipitation Mitjans, F., et al. 1995 J. Cell Sci. 108, 2825.