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437695 Anti-Lipoic Acid Rabbit pAb

437695
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Species ReactivityHostAntibody Type
A Broad Range Of SpeciesRbPolyclonal Antibody

Products

Numero di catalogoConfezionamento Qtà/conf
437695-100UL Fiala di plastica 100 ul
Description
OverviewRecognizes native lipoic acid. Does not recognize lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products.
Catalogue Number437695
Brand Family Calbiochem®
SynonymsAnti-LA
References
ReferencesSasaki, M., et al. 2000. J. Autoimmun. 15, 51.
Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53.
Patrick. L. 2000. Altern. Med. Rev. 5, 290.
Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123.
Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.
Product Information
FormLiquid
Formulationserum diluted in buffer, 50% glycerol, pH 7.5.
PreservativeNone
Quality LevelMQ100
Applications
Key Applications Paraffin Sections
Enzyme-Linked Immunosorbent Assay
Frozen Sections
Immunoblotting (Western Blotting)
Application NotesELISA (1:500-1:1000)
Frozen Sections (1:50-1:500)
Immunoblotting (1:1000-1:10,000)
Paraffin Sections (1:50-1:500)
Application CommentsDoes not bind lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products. Useful for assessing whether protein-bound lipoic acids have undergone certain forms of oxidative modification. The presence of protein-bound lipoic acid can be used as a marker for mitochondria. Variables associated with assay conditions will dictate the optimal working dilution.
Biological Information
Immunogenlipoic acid conjugated to KLH
HostRabbit
IsotypeIgG
Species Reactivity
  • A Broad Range Of Species
Antibody TypePolyclonal Antibody
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Dry Ice Only
Toxicity Standard Handling
Storage ≤ -70°C
Avoid freeze/thaw Avoid freeze/thaw
Do not freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Anti-Lipoic Acid Rabbit pAb MSDS

Titolo

Scheda di sicurezza (MSDS) 

Anti-Lipoic Acid Rabbit pAb Certificati d'Analisi

TitoloNumero di lotto
437695

Riferimenti bibliografici

Panoramica delle referenze
Sasaki, M., et al. 2000. J. Autoimmun. 15, 51.
Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53.
Patrick. L. 2000. Altern. Med. Rev. 5, 290.
Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123.
Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-August-2007 RFH
SynonymsAnti-LA
ApplicationELISA (1:500-1:1000)
Frozen Sections (1:50-1:500)
Immunoblotting (1:1000-1:10,000)
Paraffin Sections (1:50-1:500)
DescriptionRabbit polyclonal antibody supplied as diluted serum. Recognizes native lipoic acid and lipoic acid covalently attached to proteins.
BackgroundLipoic acid is a sulfur-containing substance that is readily converted to and from its reduced form, dihydrolipoic acid. It acts as a coenzyme in reactions that occur in the Krebs cycle; specifically it is involved in the decarboxylation of pyruvate and some other alpha-keto acids. Protein-bound lipoic acids such as E2 subunits, α-ketoglutarate dehydrogenase, or pyruvate dehydrogenase have been shown to be highly susceptible to free radical-derived oxidative modification. Lipoic acid is able to deactivate both fat and water soluble free radicals and thereby protect both lipoproteins and membranes; no other anti-oxidant can do this. It has also shown great promise in the treatment of HIV and in diabetes.
HostRabbit
Immunogenlipoic acid conjugated to KLH
IsotypeIgG
Speciesa broad range of species
FormLiquid
Formulationserum diluted in buffer, 50% glycerol, pH 7.5.
PreservativeNone
CommentsDoes not bind lipoic acid modified by 4-HNE (4-hydroxy-2-noneal) and other lipid peroxidation products. Useful for assessing whether protein-bound lipoic acids have undergone certain forms of oxidative modification. The presence of protein-bound lipoic acid can be used as a marker for mitochondria. Variables associated with assay conditions will dictate the optimal working dilution.
Storage ≤ -70°C
Avoid freeze/thaw
Do Not Freeze Ok to freeze
Special InstructionsFollowing initial thaw, aliquot and freeze (-70°C).
Toxicity Standard Handling
ReferencesSasaki, M., et al. 2000. J. Autoimmun. 15, 51.
Heitzer, T., et al. 2001. Free Radic. Biol. Med. 31, 53.
Patrick. L. 2000. Altern. Med. Rev. 5, 290.
Shi, S.S., et al. 1999. Antioxid. Redox Signal 1, 123.
Humphries, K.M. and Szeda, L.I. 1998. Biochemistry 37, 15835.