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197226 BCRP Inhbitor - Calbiochem

197226
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₂H₁₉N₃O₅

Products

Numero di catalogoConfezionamento Qtà/conf
197226-10MG Bottiglia di vetro 10 mg
Description
OverviewA non-tetrahydroisoquinoline BCRP specific inhibitor based on the anthranilic acid scaffold, that displays an IC50 of 1.39 µM in a Hoechst 33343 assay in stably transfected MDCK BCRP cells, which is ˜50-fold more potent than novobiocin (IC50 = 65 µM), and shows no effect towards other ATP binding cassette (ABC) transporters P-gp and MRP1 at up to a concentration of 10 µM. It is shown to be an allosteric inhibitor in enzyme kinetics assays in the presence of BCRP specific substrates pheophorbide A and imitanib, and does not lead to a decrease in cell viability up to a concentration of 10 µM.
Catalogue Number197226
Brand Family Calbiochem®
SynonymsN-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
References
ReferencesPick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.
Product Information
FormOff-white solid
Hill FormulaC₂₂H₁₉N₃O₅
Chemical formulaC₂₂H₁₉N₃O₅
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

BCRP Inhbitor - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

BCRP Inhbitor - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
197226

Riferimenti bibliografici

Panoramica delle referenze
Pick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision23-February-2011 RFH
SynonymsN-(4-(2-hydroxyethyl)phenyl)-2-(4-nitrobenzamido)benzamide
DescriptionA non-tetrahydroisoquinoline BCRP specific inhibitor based on the anthranilic acid scaffold, that displays an IC50 of 1.39 µM in a Hoechst 33343 assay in stably transfected MDCK BCRP cells, which is ˜50-fold more potent than novobiocin (IC50 = 65 µM), and shows no effect towards other ATP binding cassette (ABC) transporters P-gp and MRP1 at up to a concentration of 10 µM. It is shown to be an allosteric inhibitor in enzyme kinetics assays in the presence of BCRP specific substrates pheophorbide A and imitanib, and does not lead to a decrease in cell viability up to a concentration of 10 µM.
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₁₉N₃O₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesPick, A. et al. 2010. Chem. Med. Chem. 5, 1498.
Klinkhammer, W., et al. 2009. Bioorg. Med. Chem. 17, 2524.