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208733 Calpain Inhibitor Set - Calbiochem

208733
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Products

Numero di catalogoConfezionamento Qtà/conf
208733-1SET Bottiglia di vetro 1 set
Description
OverviewContains 5 mg of ALLN (Cat. No. 208719), 25 mg of Calpain Inhibitor III (Cat. No. 208722), 5 mg of Calpeptin (Cat. No. 03-34-0051), 1 mg of EST (Cat. No. 330005), and 5 mg of PD 150606 (Cat. No. 513022).
Catalogue Number208733
Brand Family Calbiochem®
References
ReferencesJohnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011.
Kampfl, A., et al. 1997. J. Neurotauma 14, 121.
Sorimachi, H., et al., 1997. Biochem. J. 328, 721.
Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412.
Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628.
Goll, D.E., et al. 1992. BioEssays 14, 549.
Product Information
FormSolid
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary Targetcalpain 1, calpain 2
Primary Target K<sub>i</sub>8 nM
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Multiple Toxicity Values, refer to MSDS
Storage -20°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Calpain Inhibitor Set - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Calpain Inhibitor Set - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
208733

Riferimenti bibliografici

Panoramica delle referenze
Johnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011.
Kampfl, A., et al. 1997. J. Neurotauma 14, 121.
Sorimachi, H., et al., 1997. Biochem. J. 328, 721.
Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412.
Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628.
Goll, D.E., et al. 1992. BioEssays 14, 549.

Brochure

Titolo
Caspases and other Apoptosis Related Tools Brochure
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision28-May-2008 RFH
DescriptionCalpains are a family of calcium-dependent thiol-proteases that act on a wide variety of cytoskeletal, membrane-associated, and regulatory proteins. There are two major isoforms: calpain I (µ-form) and calpain II (m-form), which differ in their calcium requirement for activation Calpains are composed of heterodimers of 80 kDa and a 30 kDa subunits. The 80 kDa unit has the catalytic site and is unique to each isozyme, whereas the 30 kDa unit is the regulatory subunit and is common to both µ- and m-isozymes.

More recently, attention has been focused on the pathological significance of calcium accumulation in the central nervous system following cerebral ischemia and traumatic brain injury. Over-activation of NMDA, kainate, and AMPA receptors in the brain leads to sustained influx of Ca2+ through the voltage-gated calcium channels. Overexpression of calpains has been positively linked to both acute and chronic neurodegenerative processes including ischemia, trauma, and Alzheimer's disease. In Alzheimer's disease the ratio of active (76 kDa) to inactive (80 kDa) µ-calpain is reported to be much higher Calpain-dependent proteolysis is usually the late-stage common pathway towards cell death induced by excitotoxic compounds, hence, a selective inhibition of calpains to limit neuronal damage appears to be a viable therapeutic measure.
FormSolid
Intert gas (Yes/No) Packaged under inert gas
Storage -20°C
Protect from moisture
Protect from light
Do Not Freeze Ok to freeze
Toxicity Multiple Toxicity Values, refer to MSDS
ReferencesJohnson, G.V.W., and Guttmann, R.P. 1997. BioEssays 19, 1011.
Kampfl, A., et al. 1997. J. Neurotauma 14, 121.
Sorimachi, H., et al., 1997. Biochem. J. 328, 721.
Bartus, R.T., et al. 1995. Neurol. Res. 17, 249.
Wang, K.K.W., and Yuen, P-W. 1994. Trends Pharmacol. Sci. 15, 412.
Saito, K., et al. 1993. Proc. Natl. Acad. Sci. USA 90, 2628.
Goll, D.E., et al. 1992. BioEssays 14, 549.