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218860 Casein Kinase II Inhibitor VIII - Calbiochem

218860
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₈H₁₄N₂O₄S

Products

Numero di catalogoConfezionamento Qtà/conf
218860-10MG Bottiglia di vetro 10 mg
Description
OverviewA cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50 = 32 and 46 nM against CK2α and CK2α', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50 = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).
Catalogue Number218860
Brand Family Calbiochem®
Synonyms4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII
References
ReferencesHou, Z., et al. 2012. J. Med. Chem. 55, 2899.
Product Information
FormOff-white solid
Hill FormulaC₁₈H₁₄N₂O₄S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCK2
Primary Target IC<sub>50</sub>32 and 46 nM for CK2&alpha
Secondary targetDYRK1B, Flt-3
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Casein Kinase II Inhibitor VIII - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Casein Kinase II Inhibitor VIII - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
218860

Riferimenti bibliografici

Panoramica delle referenze
Hou, Z., et al. 2012. J. Med. Chem. 55, 2899.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision17-June-2013 JSW
Synonyms4-(2-(4-Methoxybenzamido)thiazol-5-yl)benzoic acid, CK2 Inhibitor VIII, DYRK1B Inhibitor, Flt-3 Inhibitor VII
DescriptionA cell-permeable thiazolamide compound that acts as a potent, reversible, and ATP-competitive inhibitor against casein kinase-2/CK2 (IC50 = 32 and 46 nM against CK2α and CK2α', respectively), as well as DYRK1B and FLt-3 (82% and 76% inhibition, respectively, at 30 nM), while diplaying reduced or little potency toward other targets in a 70-kinase panel selectivity profile study. Shown to effectively block the proliferation of a variety of cancer cells (IC50 = 2.6, 1.6, and 2.4 µM, in A549, HCT116, and MCF-7 cultures, respectively).
FormOff-white solid
Intert gas (Yes/No) Packaged under inert gas
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (50 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesHou, Z., et al. 2012. J. Med. Chem. 55, 2899.