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219415 Cathepsin Inhibitor I - Calbiochem

219415
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₆H₂₅N₃O₆

Products

Numero di catalogoConfezionamento Qtà/conf
219415-1MG Fiala di plastica 1 mg
Description
OverviewCell-permeable cysteine protease inhibitor. Inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1 sec-1), cathepsin L (k2/Ki = 3.8 x 105 M-1 sec-1), cathepsin S (k2/Ki = 4.2 x 104 M-1 sec-1), and papain (k2/Ki = 2.4 x 103 M-1 sec-1).
Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).
Catalogue Number219415
Brand Family Calbiochem®
SynonymsZ-FG-NHO-Bz, CATI -1
References
ReferencesZhu, D. and Uckun, F.M. 2000. Clin. Cancer Res. 6, 2064.
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.
Product Information
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₆H₂₅N₃O₆
Chemical formulaC₂₆H₂₅N₃O₆
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary Targetcathepsin B
Primary Target K<sub>i</sub>k₂/Ki = 8.9 x 10³ M⁻¹sec⁻¹ for cathepsin B
Purity>90% by HPLC
Physicochemical Information
Cell permeableY
Peptide SequenceZ-Phe-Gly-NHO-Bz
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +15°C to +30°C
Protect from Light Protect from light
Protect from Moisture Protect from moisture
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Cathepsin Inhibitor I - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Cathepsin Inhibitor I - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
219415

Riferimenti bibliografici

Panoramica delle referenze
Zhu, D. and Uckun, F.M. 2000. Clin. Cancer Res. 6, 2064.
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.

Brochure

Titolo
Cathepsins and Related Products Technical Bulletin
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision18-July-2011 JSW
SynonymsZ-FG-NHO-Bz, CATI -1
DescriptionCysteine protease inhibitor. Selectively inhibits cathepsin B (k2/Ki = 8.9 x 103 M-1sec-1), cathepsin L (k2/Ki = 3.8 x 105 M-1sec-1), cathepsin S (k2/Ki = 4.2 x 104 M-1sec-1), and papain (k2/Ki = 2.4 x 103 M-1sec-1). Half-life in buffered solution (pH 5-9) = 25 h (30°C); 300 h (0°C).
FormWhite solid
Chemical formulaC₂₆H₂₅N₃O₆
Peptide SequenceZ-Phe-Gly-NHO-Bz
Structure formulaStructure formula
Purity>90% by HPLC
SolubilityAcetonitrile, DMSO, or Ethanol
Storage +15°C to +30°C
Protect from moisture
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesZhu, D. and Uckun, F.M. 2000. Clin. Cancer Res. 6, 2064.
Demuth, H.-U., et al. 1996. Biochim. Biophys. Acta 1295, 179.
Brömme, D., and Demuth, H.-U. 1994. Methods Enzymol. 244, 671.