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217720 Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem

217720
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₉H₇N₅ 40254-90-8

Products

Numero di catalogoConfezionamento Qtà/conf
217720-5MG Fiala di plastica 5 mg
Description
OverviewA 3-amino substituted pyrazoloquinoxaline compound that acts as a selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdks; IC50 = 0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively). Also shown to inhibit GSK-3β with (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 > 10 µM).
Catalogue Number217720
Brand Family Calbiochem®
Synonyms3-Amino-1H-pyrazolo[3,4-b]quinoxaline
References
ReferencesOrtega, M.A., et al. 2002. Bioorg. Med. Chem. 10, 2177.
Product Information
CAS number40254-90-8
ATP CompetitiveN
FormRed solid
Hill FormulaC₉H₇N₅
Chemical formulaC₉H₇N₅
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk1/cyclin B, Cdk5/p25
Primary Target IC<sub>50</sub>0.6 µM and 0.4 µM for Cdk1/cyclin B and Cdk5/p25, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableN
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
217720

Riferimenti bibliografici

Panoramica delle referenze
Ortega, M.A., et al. 2002. Bioorg. Med. Chem. 10, 2177.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-October-2007 RFH
Synonyms3-Amino-1H-pyrazolo[3,4-b]quinoxaline
DescriptionA selective inhibitor of cyclin-dependent kinases 1 and 5 (Cdk1/Cdk5) (IC50 = 600 nM for Cdk1/cyclin B and 400 nM for Cdk5/p25). Also shown to inhibit glycogen synthase kinase-3β (GSK-3β) (IC50 = 1 µM). Does not inhibit Cdc25 phosphatase activity (IC50 > 10 µM).
FormRed solid
Intert gas (Yes/No) Packaged under inert gas
CAS number40254-90-8
Chemical formulaC₉H₇N₅
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesOrtega, M.A., et al. 2002. Bioorg. Med. Chem. 10, 2177.