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217699 Cdk1 Inhibitor IV, RO-3306 - Calbiochem

217699
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₈H₁₃N₃OS₂

Products

Numero di catalogoConfezionamento Qtà/conf
217699-5MG Bottiglia di vetro 5 mg
Description
OverviewA cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥ 2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines. Also available as a 10 mM solution in DMSO (Cat. No. 217721).
Catalogue Number217699
Brand Family Calbiochem®
References
ReferencesVassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
Product Information
ATP CompetitiveY
FormBrown solid
Hill FormulaC₁₈H₁₃N₃OS₂
Chemical formulaC₁₈H₁₃N₃OS₂
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCdk1
Primary Target K<sub>i</sub>35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Cdk1 Inhibitor IV, RO-3306 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Cdk1 Inhibitor IV, RO-3306 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
217699

Riferimenti bibliografici

Panoramica delle referenze
Vassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-June-2007 JSW
DescriptionA cell-permeable quinolinyl thiazolinone compound that acts as a potent and ATP-competitive inhibitor of Cdk1 (Ki = 35 nM and 110 nM for Cdk1/B1 and Cdk1/A, respectively). It affects Cdk2/E, PKCδ, and SGK only at much higher concentrations (Ki = 340, 318, and 497 nM, respectively), and shows little effect against Cdk4/D and six other commonly studied kinases (Ki ≥2 µM). Short-term treatment for up to 20 hrs results in fully reversible G2/M cell cycle arrest, while prolonged treament (>48 hrs) results in apoptotic cell death in proliferating cancer cells, but not in nontumorigenic epithelial cell lines.
FormBrown solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₈H₁₃N₃OS₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Irritant
ReferencesVassilev, L.T., et al. 2006. Proc. Natl. Acad. Sci. USA 103, 10660.