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317641 Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem

The Dipeptidylpeptidase IV Inhibitor III, also referenced under CAS 866396-34-1, controls the biological activity of Dipeptidylpeptidase IV. This small molecule/inhibitor is primarily used for Protease Inhibitors applications.

Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem: MSDS (material safety data sheet) o SDS, certificato d’analisi (CoA) e certificato di qualità (CoQ), dossier, brochure e altri documenti disponibili.

Sinonimi: 1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III

317641
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
866396-34-1C₁₄H₂₀N₄O₂ • HCl

Products

Numero di catalogoConfezionamento Qtà/conf
317641-5MG Bottiglia di vetro 5 mg
Description
OverviewAn orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.
Catalogue Number317641
Brand Family Calbiochem®
Synonyms1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
References
ReferencesWright, S.W., et al. 2006. J. Med. Chem. 49, 3068.
Product Information
CAS number866396-34-1
FormWhite solid
Hill FormulaC₁₄H₂₀N₄O₂ • HCl
Chemical formulaC₁₄H₂₀N₄O₂ • HCl
Hygroscopic Hygroscopic
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36/37/39

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing, gloves and eye/face protection.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Dipeptidylpeptidase IV Inhibitor III - CAS 866396-34-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
317641

Riferimenti bibliografici

Panoramica delle referenze
Wright, S.W., et al. 2006. J. Med. Chem. 49, 3068.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision06-November-2008 RFH
Synonyms1-(((1-(Hydroxymethyl)cyclopentyl)amino)acetyl)-2,5-cis-pyrrolidinedicarbonitrile, HCl, DPP IV Inhibitor III
DescriptionAn orally bioavailable dicyanopyrrolidine compound that acts as a slow-binding and active site-targeting inhibitor of DPP IV (IC50 = 106 nM using recombinant human DPP IV and 38, 69, 92, and 100 nM in inhibiting DPP IV activity in plasma from rat, human, monkey, and dog, respectively) with little activity against DPP II, DPP III, DPP VIII, DPP IX, FAP, or APP even at concentrations as high as 30 µM. Reported to lower blood DPP IV activity and augment GLP-1 response in dog and mouse in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number866396-34-1
Chemical formulaC₁₄H₂₀N₄O₂ • HCl
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityEthanol (20 mg/ml), H₂O (20 mg/ml), or PBS (20 mg/ml)
Storage Protect from light
+2°C to +8°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 1 month at -20°C.
Toxicity Standard Handling
ReferencesWright, S.W., et al. 2006. J. Med. Chem. 49, 3068.