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324483 Ebselen - CAS 60940-34-3 - Calbiochem

324483
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₁₃H₉NOSe 60940-34-3

Products

Numero di catalogoConfezionamento Qtà/conf
324483-5MG Bottiglia di vetro 5 mg
Description
OverviewA cell-permeable, non-selective inhibitor of COX-1 and COX-2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent active against acute focal ischemic injury. Inhibits LPS-induced NF-κB nuclear translocation and LPS-induced phosphorylation of JNK.
Catalogue Number324483
Brand Family Calbiochem®
Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
References
ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
Wang, J.F., et al. 1992. Hepatology 5, 112.
Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.
Product Information
CAS number60940-34-3
ATP CompetitiveN
FormLyophilized solid
Hill FormulaC₁₃H₉NOSe
Chemical formulaC₁₃H₉NOSe
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetCOX-1, COX-2
Purity≥98% by TLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Ebselen - CAS 60940-34-3 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Ebselen - CAS 60940-34-3 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
324483

Riferimenti bibliografici

Panoramica delle referenze
Shimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
Wang, J.F., et al. 1992. Hepatology 5, 112.
Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.

Brochure

Titolo
Alzheimer's Disease Brochure & Technical Guide
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-June-2008 RFH
Synonyms2-Phenyl-1,2-benzisoselenazol-3(2H)-one, PZ51
DescriptionNon-selective, cell-permeable, inhibitor of the cyclooxygenase activity of prostaglandin H synthase 1 and 2. An excellent scavenger of peroxynitrite. Glutathione peroxidase mimetic. Inhibits radiation-induced apoptosis in thymocytes by scavenging peroxides. A neuroprotective agent against acute focal ischemic injury.
FormLyophilized solid
CAS number60940-34-3
Chemical formulaC₁₃H₉NOSe
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityDMSO (5 mg/ml) or Ethanol
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstituion, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesShimohashi, N., et al. 2000. J. Cell Biochem. 78, 595.
Ramakrishnan, N., et al. 1996. Biochem. Pharmacol. 51, 1443.
Ullrich, V., et al. 1996. Biochem. Pharmacol. 52, 15.
Dawson, D.A., et al. 1995. Neurosci. Lett. 185, 65.
Wang, J.F., et al. 1992. Hepatology 5, 112.
Maiorino, M., et al. 1988. Biochem. Pharmacol. 37, 2267.
Parnham, M.J., and Graf, E. 1987. Biochem. Pharmacol. 36, 3095.
Parnham, M.J., and Kindt, S. 1984. Biochem. Pharmacol. 33, 3247.