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341216 Ezrin Inhibitor, NSC668394 - Calbiochem

341216
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₇H₁₂Br₂N₂O₃

Products

Numero di catalogoConfezionamento Qtà/conf
341216-10MG Bottiglia di vetro 10 mg
Description
OverviewA cell-permeable, quinoline that binds directly to ezrin (Kd = 12.6 µM) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50 = 8.1 µM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 µM. At 10 µM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10 µM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vivo at 2.26 mg/kg/day.
Catalogue Number341216
Brand Family Calbiochem®
Synonyms7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione
References
ReferencesBulut, G., et al. 2011. Oncogene 31, 269.
Product Information
FormReddish orange solid
Hill FormulaC₁₇H₁₂Br₂N₂O₃
Chemical formulaC₁₇H₁₂Br₂N₂O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Ezrin Inhibitor, NSC668394 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Ezrin Inhibitor, NSC668394 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
341216

Riferimenti bibliografici

Panoramica delle referenze
Bulut, G., et al. 2011. Oncogene 31, 269.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-June-2012 JSW
Synonyms7-(3,5-dibromo-4-hydroxyphenethylamino)quinoline-5,8-dione
DescriptionA cell-permeable, quinoline that binds directly to ezrin (Kd = 12.6 µM) in a reversible manner, and inhibits PKCι-mediated ezrin phosphorylation at Thr567 (IC50 = 8.1 µM) and ezrin-actin binding, in vitro. It also inhibits murine osteosarcoma K7M2 cell invasion in a monolayer of HUVEC cells, dose-dependently, from 1 to 10 µM. At 10 µM, it causes a unique developmental defect in zebrafish, characterized by reduced motility of eye progenitor cells. Furthermore, this small molecule prevents metastatic growth in an ex vivo mouse lung organ culture assay at 10 µM and attenuates ezrin-dependent OS metastatic growth in mouse lung model in vivo at 2.26 mg/kg/day.
FormReddish orange solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₇H₁₂Br₂N₂O₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (50 mg/ml; clear, red-orange solution)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesBulut, G., et al. 2011. Oncogene 31, 269.