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341598 Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem

341598
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₁H₁₄N₂Na₂O₉S₂

Products

Numero di catalogoConfezionamento Qtà/conf
341598-10MG 10 mg
Description
OverviewA small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC50 = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC50 = 24.0 ±6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC50 = 20.3 µM ±5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ±2 (FGF-2 + NSC37203).
Catalogue Number341598
Brand Family Calbiochem®
References
ReferencesColombo, G., et al. 2010. J. Biol. Chem. 285, 8733.
Product Information
FormBrown solid
Hill FormulaC₂₁H₁₄N₂Na₂O₉S₂
Chemical formulaC₂₁H₁₄N₂Na₂O₉S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity>95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Fibroblast Growth Factor-2 Inhibitor, NSC37204 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
341598

Riferimenti bibliografici

Panoramica delle referenze
Colombo, G., et al. 2010. J. Biol. Chem. 285, 8733.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision07-December-2010 RFH
DescriptionA small molecule, compound that is shown to compete with the binding domain of TSP-1 against angiogenic factor FGF-2 (IC50 = 1.3 µM) in a dose-dependent manner and prevents the binding of FGF-2 to HSPG on endothelial cells (IC50 = 24.0 ± 6.9 µM), in vitro. It also demonstrates anti-growth properties in FGF-2-induced, but not serum-induced, endothelial cells (IC50 = 20.3 µM ± 5.9 µM). In CAM assays in vivo, where angiogenesis is induced by FGF-2 embedded in gelatin sponges, the presence of the small molecule (0.5 µg) reduces the mean number of blood vessels entering the sponge from 26 ±4 (FGF-2 alone) to 10 ± 2 (FGF-2 + NSC37203).
FormBrown solid
Chemical formulaC₂₁H₁₄N₂Na₂O₉S₂
Structure formulaStructure formula
Purity>95% by HPLC
SolubilityDMSO (5 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesColombo, G., et al. 2010. J. Biol. Chem. 285, 8733.