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344580 FtsZ Polymer Stabilizer, PC190723 - Calbiochem

344580
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₄H₈ClF₂N₃O₂S

Products

Numero di catalogoConfezionamento Qtà/conf
344580-5MG Bottiglia di vetro 5 mg
Description
OverviewA benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 mg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC50 = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubulin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.
Catalogue Number344580
Brand Family Calbiochem®
Synonyms3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer
References
ReferencesElsen, N. L., et al. 2012. J. Am. Chem. Soc. 134, 12342.
Andreu, J. M., et al. 2010. J. Biol. Chem. 285, 14239.
Haydon, D. J., et al. 2008. Science, 321, 1673.
Sorto, N. A., et al. 2010. J. Org. Chem. 75, 7946.
Product Information
FormTan powder
Hill FormulaC₁₄H₈ClF₂N₃O₂S
Chemical formulaC₁₄H₈ClF₂N₃O₂S
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetFtsZ
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

FtsZ Polymer Stabilizer, PC190723 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

FtsZ Polymer Stabilizer, PC190723 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
344580

Riferimenti bibliografici

Panoramica delle referenze
Elsen, N. L., et al. 2012. J. Am. Chem. Soc. 134, 12342.
Andreu, J. M., et al. 2010. J. Biol. Chem. 285, 14239.
Haydon, D. J., et al. 2008. Science, 321, 1673.
Sorto, N. A., et al. 2010. J. Org. Chem. 75, 7946.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision11-January-2013 JSW
Synonyms3-((6-chlorothiazolo[5,4-b]pyridin-2-yl)methoxy)-2,6-difluorobenzamide, FtsZ Polymer-stabilizing Agent, Filamenting Temperature-Sensitive Mutant Z Polymer Stabilizer
DescriptionA benzamide ether derivative that exhibits potent bactericidal activity against Staphylococcus aureus and Bacillus subtilis (minimum inhibitory concentration = 0.5 to 1 mg/ml), but does not affect E. coli, yeast, or human hepatocytes. Shown to reduce GTPase activity and induce FtsZ (a prokaryotic homologue of tubulin) polymerization in S. aureus in a dose-dependent manner. Reported to directly inhibit the GTPase activity of FtsZ in a concentration dependent manner (IC50 = 55 ng/ml). Shown to bind between the C-ternimal domain and helix 7 in a region analogous to the Taxol binding site of tubuin. Increases the survival rate to 100% in mice subjected to a lethal dose of S. aureus.
FormTan powder
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₄H₈ClF₂N₃O₂S
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (10 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesElsen, N. L., et al. 2012. J. Am. Chem. Soc. 134, 12342.
Andreu, J. M., et al. 2010. J. Biol. Chem. 285, 14239.
Haydon, D. J., et al. 2008. Science, 321, 1673.
Sorto, N. A., et al. 2010. J. Org. Chem. 75, 7946.