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344827 Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose - Calbiochem

344827
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₂H₁₇FO₇

Products

Numero di catalogoConfezionamento Qtà/conf
344827-10MG Bottiglia di vetro 10 mg
Description
OverviewA cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic. Treatment of HL-60 cells with this inhibitor shows complete abolition of Lewis-X and SLex within 3 days. Also abolishes P-selectin binding and exhibits faster rolling cells on E-selectin and P-selectin coated surfaces. Does not affect cell viability or their doubling time even at 200 µM levels.
Catalogue Number344827
Brand Family Calbiochem®
Synonyms(3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate
References
ReferencesRillahan, C., et al. 2012.. Nat. Chem. Bio. 8, 661.
Product Information
FormWhite solid
Hill FormulaC₁₂H₁₇FO₇
Chemical formulaC₁₂H₁₇FO₇
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ200
Applications
Biological Information
Primary TargetFucosyltransferase
Purity≥98% by NMR
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Fucosyltransferase Inhibitor, 2F-Peracetyl-Fucose - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
344827

Riferimenti bibliografici

Panoramica delle referenze
Rillahan, C., et al. 2012.. Nat. Chem. Bio. 8, 661.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision24-October-2012 JSW
Synonyms(3S,4R,5R,6S)-3-fluoro-6-methyltetrahydro-2H-pyran-2,4,5-triyl triacetate
DescriptionA cell-permeable fluorinated fucose derivative that acts as an inhibitor of fucosyltransferases following its uptake and metabolic transformation into a GDP-fucose mimetic. Treatment of HL-60 cells with this inhibitor shows complete abolition of Lewis-X and SLex within 3 days. Also abolishes P-selectin binding and exhibits faster rolling cells on E-selectin and P-selectin coated surfaces. Does not affect cell viability or their doubling time even at 200 µM levels.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₂H₁₇FO₇
Structure formulaStructure formula
Purity≥98% by NMR
SolubilityDMSO (10 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Standard Handling
ReferencesRillahan, C., et al. 2012.. Nat. Chem. Bio. 8, 661.