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361568 GSK-3β Inhibitor XXV - Calbiochem

361568
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₅H₁₁ClN₄O₃

Products

Numero di catalogoConfezionamento Qtà/conf
361568-10MG Bottiglia di vetro 10 mg
Description
OverviewA blood brain barrier permeable oxadiazole compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3β activity (IC50 = 17.1 nM) with excellent selectivity over Cdk2 (22% inhibition at 10 µM). Shown to elevate liver glycogen levels by ~3.5- and ~4.3-fold in C57BL/6N mice when dosed at 5 and 15 mg/kg (i.p.) amounts.
Catalogue Number361568
Brand Family Calbiochem®
Synonyms5-(4-Nitrophenyl)-N-(3-chloro-4-methyl)phenyl-1,3,4-oxadiazol-2-amine, N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine, M SEW00923SC
References
ReferencesKhanfar, M.A., et al. 2010. J. Med. Chem. 53, 8534.
Product Information
FormYellow solid
Hill FormulaC₁₅H₁₁ClN₄O₃
Chemical formulaC₁₅H₁₁ClN₄O₃
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥99% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped at Ambient Temperature or with Blue Ice or with Dry Ice
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

GSK-3β Inhibitor XXV - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Riferimenti bibliografici

Panoramica delle referenze
Khanfar, M.A., et al. 2010. J. Med. Chem. 53, 8534.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision27-July-2012 JSW
Synonyms5-(4-Nitrophenyl)-N-(3-chloro-4-methyl)phenyl-1,3,4-oxadiazol-2-amine, N-(3-Chloro-4-methylphenyl)-5-(4-nitrophenyl)-1,3,4-oxadiazol-2-amine, M SEW00923SC
DescriptionA blood brain barrier permeable oxadiazole compound that acts as a potent, reversible and ATP-competitive inhibitor of GSK-3β activity (IC50 = 17.1 nM) with excellent selectivity over Cdk2 (22% inhibition at 10 µM). Shown to elevate liver glycogen levels by ~3.5- and ~4.3-fold in C57BL/6N mice when dosed at 5 and 15 mg/kg (i.p.) amounts.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₁₅H₁₁ClN₄O₃
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesKhanfar, M.A., et al. 2010. J. Med. Chem. 53, 8534.