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345752 Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk

345752
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₇₀H₁₂₃N₃O₃₀ · 2NH₄

Products

Numero di catalogoConfezionamento Qtà/conf
345752-1MG Fiala di plastica 1 mg
Description
OverviewHas been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
Catalogue Number345752
Brand Family Calbiochem®
SynonymsNeu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄
References
ReferencesDeMaria, R., et al. 1997. Science 277, 1652.
Product Information
FormWhite solid
Hill FormulaC₇₀H₁₂₃N₃O₃₀ · 2NH₄
Chemical formulaC₇₀H₁₂₃N₃O₃₀ · 2NH₄
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥98% by TLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
R PhraseR: 36/37/38

Irritating to eyes, respiratory system and skin.
S PhraseS: 26-36

In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk MSDS

Titolo

Scheda di sicurezza (MSDS) 

Ganglioside GD₃, Disialo, Diammonium Salt, Bovine Buttermilk Certificati d'Analisi

TitoloNumero di lotto
345752

Riferimenti bibliografici

Panoramica delle referenze
DeMaria, R., et al. 1997. Science 277, 1652.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-March-2008 JSW
SynonymsNeu5Acα2,8Neu5Acα2,3Galβ1,4Glcβ1,1 Ceramide, 2NH₄
DescriptionHas been characterized as one of the most important tumor-specific antigens in individuals with malignant melanoma. Reported to disrupt mitochondrial transmembrane potential and induce apoptosis in tumor cells by a caspase-independent mechanism. Antibodies to GD3 can induce partial remission of tumor growth in animals and in humans via enhancement of cytotoxic and proliferative responses of lymphocytes. M.W. 1577.0 (based on tricosanoyl - 23:0).
FormWhite solid
Chemical formulaC₇₀H₁₂₃N₃O₃₀ · 2NH₄
Structure formulaStructure formula
Purity≥98% by TLC
SolubilityChloroform:Methanol (2:1) or H₂O (1 mg/ml)
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to months at -20°C.
Toxicity Irritant
ReferencesDeMaria, R., et al. 1997. Science 277, 1652.