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370674 Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem

370674
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₁₀H₁₀BrN₅O₆PS · Na

Products

Numero di catalogoConfezionamento Qtà/conf
370674-5UMOL Fiala di plastica 5 umol
Description
OverviewA potent, cell-permeable, and metabolically stable inhibitor of protein kinase G (PKG; Ki = 4 µM). Acts as a cyclic nucleotide-gated channel agonist (EC50 = 173.5 µM). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases. Note: 5 µmol = 2.31 mg.
Catalogue Number370674
Brand Family Calbiochem®
SynonymsRp-8-Br-cGMPS, Na, PKG Inhibitor II
References
ReferencesWei, J.Y., et al. 1998. J. Mol. Neurosci. 10, 53.
Nakamura, A., et al. 1996. Br. J. Pharmacol. 117, 407.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
Nakazawa, M., et al. 1994. Eur. J. Pharmacol. 253, 179.
Zhuo, M., et al. 1994. Nature 368, 635.
Product Information
ATP CompetitiveN
DeclarationSold under license of Patent DE 3,802,865.4 issued to BIOLOG LSI.
FormLyophilized
Hill FormulaC₁₀H₁₀BrN₅O₆PS · Na
Chemical formulaC₁₀H₁₀BrN₅O₆PS · Na
Hygroscopic Hygroscopic
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetPKG
Primary Target K<sub>i</sub>4 µM against protein kinase G (PKG)
Purity≥99% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Guanosine 3ʹ,5ʹ-cyclic Monophosphorothioate, 8-Bromo-, Rp-Isomer, Sodium Salt - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
370674

Riferimenti bibliografici

Panoramica delle referenze
Wei, J.Y., et al. 1998. J. Mol. Neurosci. 10, 53.
Nakamura, A., et al. 1996. Br. J. Pharmacol. 117, 407.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
Nakazawa, M., et al. 1994. Eur. J. Pharmacol. 253, 179.
Zhuo, M., et al. 1994. Nature 368, 635.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision21-January-2008 JSW
SynonymsRp-8-Br-cGMPS, Na, PKG Inhibitor II
DescriptionA potent cell-permeable, metabolically stable inhibitor of cGMP-dependent protein kinase (PKG). Significantly more lipophilic and membrane-permeable than cGMP or Rp-cGMPS. Resistant to mammalian cyclic nucleotide-dependent phosphodiesterases.
FormLyophilized
Chemical formulaC₁₀H₁₀BrN₅O₆PS · Na
Structure formulaStructure formula
Purity≥99% by HPLC
SolubilityH₂O (1 mg/ml)
Storage -20°C
Hygroscopic
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesWei, J.Y., et al. 1998. J. Mol. Neurosci. 10, 53.
Nakamura, A., et al. 1996. Br. J. Pharmacol. 117, 407.
Van Uffelen, B.E., et al. 1996. J. Leukoc. Biol. 60, 94.
Nakazawa, M., et al. 1994. Eur. J. Pharmacol. 253, 179.
Zhuo, M., et al. 1994. Nature 368, 635.