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382185 HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem

382185
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₂₀H₂₆N₂O₂S₂ 848354-66-5

Products

Numero di catalogoConfezionamento Qtà/conf
382185-2MG Bottiglia di vetro 2 mg
Description
OverviewA cell-permeable S-isobutyryl prodrug that is processed intracellularly to form the potent HDAC inhibitor NCH-31 (IC50 = 48 and 170 nM, respectively, using partially purified HDAC1 or HeLa nuclear extract) that is predicted to exhibit a similar HADC binding mode as that of SAHA with its sulfhydryl replacing SAHA's hydroxamate as the active-site zinc-targeting group. NCH-51 is shown to exhibit comparable antiproliferative (mean IC50 = 3.8 µM vs. 3.7 µM for SAHA; 48 h treatment) and apoptotic activity as SAHA against various cancer cell lines, but not PBMCs from 4 healthy individuals (IC50 >30 µM with either drug), and the antioxidant N-Acetyl-L-Cysteine (NAC; Cat. No. 106425) at 2 mM is reported to abolish the cell-growth inhibition caused by either 3 µM NCH-51 or SAHA in the Multiple Myeloma U266 cultures. Half-life in human plasma at 37 °C = 24 h.
Catalogue Number382185
Brand Family Calbiochem®
SynonymsThioisobutyric acid (S-(6-(4-phenyl-2-thiazolylcarbamoyl)hexyl) ester
References
ReferencesSanda, T., et al. 2007. Leukemia 21, 2344.
Suzuki, T., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1558.
Suzuki, T., et al. 2005. J. Med. Chem. 48, 1019.
Product Information
CAS number848354-66-5
FormWhite powder
Hill FormulaC₂₀H₂₆N₂O₂S₂
Chemical formulaC₂₀H₂₆N₂O₂S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Application Comments#31: Thiol - 7-Mercaptoheptanoic acid (4-phenyl-2-thiazolyl)amide
Biological Information
Purity≥97% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Shipped with Blue Ice or with Dry Ice
Toxicity Regulatory Review
Storage -20°C
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

HDAC Inhibitor XXII, NCH51 - CAS 848354-66-5 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
382185

Riferimenti bibliografici

Panoramica delle referenze
Sanda, T., et al. 2007. Leukemia 21, 2344.
Suzuki, T., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1558.
Suzuki, T., et al. 2005. J. Med. Chem. 48, 1019.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision14-November-2011 RFH
SynonymsThioisobutyric acid (S-(6-(4-phenyl-2-thiazolylcarbamoyl)hexyl) ester
DescriptionA cell-permeable S-isobutyryl prodrug that is processed intracellularly to form the potent HDAC inhibitor NCH-31 (IC50 = 48 and 170 nM, respectively, using partially purified HDAC1 or HeLa nuclear extract) that is predicted to exhibit a similar HADC binding mode as that of SAHA with its sulfhydryl replacing SAHA's hydroxamate as the active-site zinc-targeting group. NCH-51 is shown to exhibit comparable antiproliferative (mean IC50 = 3.8 µM vs. 3.7 µM for SAHA; 48 h treatment) and apoptotic activity as SAHA against various cancer cell lines, but not PBMCs from 4 healthy individuals (IC50 >30 µM with either drug), and the antioxidant N-Acetyl-L-Cysteine (NAC; Cat. No. 106425) at 2 mM is reported to abolish the cell-growth inhibition caused by either 3 µM NCH-51 or SAHA in the Multiple Myeloma U266 cultures. Half-life in human plasma at 37 °C = 24 h.
FormWhite powder
CAS number848354-66-5
Chemical formulaC₂₀H₂₆N₂O₂S₂
Structure formulaStructure formula
Purity≥97% by HPLC
SolubilityDMSO (100 mg/ml)
Comments#31: Thiol - 7-Mercaptoheptanoic acid (4-phenyl-2-thiazolyl)amide
Storage -20°C
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Regulatory Review
ReferencesSanda, T., et al. 2007. Leukemia 21, 2344.
Suzuki, T., et al. 2007. Bioorg. Med. Chem. Lett. 17, 1558.
Suzuki, T., et al. 2005. J. Med. Chem. 48, 1019.