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373271 Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem

373271
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₁₉H₁₈N₂OS 1001753-24-7

Products

Numero di catalogoConfezionamento Qtà/conf
373271-10MG 10 mg
Description
OverviewA cell-permeable INH1 (Cat. No. 373270) analog that contains a tri-, instead of di-, methylated aryl ring and exhibits significantly improved antiproliferative activity against MB231, MB468, HeLa, and K562 cells (IC50 = 1.7, 2.1, 2.4, and 2.5 µM, respectively) than INH1 (IC50 = 8.6, 10.5, 8.8, and 11.7 µM, respectively). Immobilized INH6 is shown to selectively pull down Hec1, but not Nek2, from HeLa cell extract. Treatment of HeLa cultures results in down-regulations of cellular Nek2 (6.25 µM , >4 h) and Hec1 (6.25 µM , >16 h), an increase in apoptotic G1 population (by 10-fold; 2.5 µM, 72 h), as well as increased mitotic abnormalities, including multipolar spindle formations and metaphase chromosome misalignment.
Catalogue Number373271
Brand Family Calbiochem®
SynonymsN-(4-(2,4,6-Trimethylphenyl)-thiazol-2-yl)-benzamide, INH6
References
ReferencesQiu, X.L., et al. 2009. J. Med. Chem. 52, 1757.
Product Information
CAS number1001753-24-7
FormWhite solid
Hill FormulaC₁₉H₁₈N₂OS
Chemical formulaC₁₉H₁₈N₂OS
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing resonstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Hec1/Nek2 Mitotic Pathway Inhibitor II, INH6 - CAS 1001753-24-7 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
373271

Riferimenti bibliografici

Panoramica delle referenze
Qiu, X.L., et al. 2009. J. Med. Chem. 52, 1757.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsN-(4-(2,4,6-Trimethylphenyl)-thiazol-2-yl)-benzamide, INH6
DescriptionA cell-permeable INH1 (Cat. No. 373270) analog that contains a tri-, instead of di-, methylated aryl ring and exhibits significantly improved antiproliferative activity against MB231, MB468, HeLa, and K562 cells (IC50 = 1.7, 2.1, 2.4, and 2.5 µM, respectively) than INH1 (IC50 = 8.6, 10.5, 8.8, and 11.7 µM, respectively). Immobilized INH6 is shown to selectively pull down Hec1, but not Nek2, from HeLa cell extract. Treatment of HeLa cultures results in down-regulations of cellular Nek2 (6.25 µM, >4 h) and Hec1 (6.25 µM, >16 h), an increase in apoptotic G1 population (by 10-fold; 2.5 µM, 72 h), as well as increased mitotic abnormalities, including multipolar spindle formations and metaphase chromosome misalignment.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number1001753-24-7
Chemical formulaC₁₉H₁₈N₂OS
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml) or Ethanol (5 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing resonstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesQiu, X.L., et al. 2009. J. Med. Chem. 52, 1757.