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382173 Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem

382173
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₂₀H₂₅N₃O₂ 937039-45-7

Products

Numero di catalogoConfezionamento Qtà/conf
382173-5MG Fiala di plastica 5 mg
Description
OverviewA cell-permeable p-tolylbenzamide and a Histone Deacetylase (HDAC) Inhibitor IV (Cat. No. 382170) analog that acts as a selective inhibitor against class I HDAC1,2,3 (IC50 = 0.15, 0.76, and 0.37 µM with 15, 30, and 180 min preincubation, respectively), while exhibiting much lower acitivity against class I HDAC8 (IC50 ≥ 5µM with 3 h preincubation) and no activity against class II HDAC4/5/7 even at concentrations as high as 180µM. Although the mode of inhibition is mechanistically competitive and reversible, due to the slow- and tight-binding nature, long preincubation is often required for effective in vitro enzyme inhibition, while 106-induced cellular H3 hyperacetylation is shown to persist for more than 6 hours after inhibitor removal by washing in GM15850 culture. 106 is reported to be less cytotoxic than TSA (Cat. No. 647925), MS-275, and SAHA (EC50 = 6.3, 0.328, 0.768, and 1.5 µM, respectively, in GM15850 killing).
Catalogue Number382173
Brand Family Calbiochem®
SynonymsN¹-(2-Aminophenyl)-N⁷-p-tolylheptanediamide, Pimelic Diphenylamide 106
References
ReferencesChou, C.J., et al. 2008. J. Biol. Chem. 283, 35402.
Product Information
CAS number937039-45-7
FormYellow solid
Hill FormulaC₂₀H₂₅N₃O₂
Chemical formulaC₂₀H₂₅N₃O₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
S PhraseS: 22-24/25-36

Do not breathe dust.
Avoid contact with skin and eyes.
Wear suitable protective clothing.
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Histone Deacetylase Inhibitor VII, 106 - CAS 937039-45-7 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
382173

Riferimenti bibliografici

Panoramica delle referenze
Chou, C.J., et al. 2008. J. Biol. Chem. 283, 35402.

Informazioni tecniche

Titolo
White Paper - The Message in the Marks: Deciphering Cancer Epigenetics
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsN¹-(2-Aminophenyl)-N⁷-p-tolylheptanediamide, Pimelic Diphenylamide 106
DescriptionA cell-permeable p-tolylbenzamide and a Histone Deacetylase (HDAC) Inhibitor IV (Cat. No. 382170) analog that acts as a selective inhibitor against class I HDAC1/2/3 (IC50 = 0.15/0.76/0.37 µM with 15/30/180 min preincubation), while exhibiting much lower acitivity against class I HDAC8 (IC50 ≥ 5µM with 3 h preincubation) and no activity against class II HDAC4/5/7 even at concentrations as high as 180µM. Although the mode of inhibition is mechanistically competitive and reversible, due to the slow- and tight-binding nature, long preincubation is often required for effective in vitro enzyme inhibition, while 106-induced cellular H3 hyperacetylation is shown to persist for more than 6 hours after inhibitor removal by washing in GM15850 culture. 106 is reported to be less cytotoxic than TSA (Cat. No. 647925), MS-275, and SAHA (EC50 = 6.3, 0.328, 0.768, and 1.5 µM, respectively, in GM15850 killing).
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number937039-45-7
Chemical formulaC₂₀H₂₅N₃O₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml) or Ethanol (2.5 mg/ml)
Storage -20°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesChou, C.J., et al. 2008. J. Biol. Chem. 283, 35402.