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401479 IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem

401479
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₉H₈N₂OS₂ 354812-17-2

Products

Numero di catalogoConfezionamento Qtà/conf
401479-1MG Fiala di plastica 1 mg
Description
OverviewA cell-permeable (thienothienyl)amino-acetamide compound that displays anti-inflammatory properties. Acts as a potent, reversible, ATP-competitive, and highly selective inhibitor of IKK-2 (IC50 = ~ 3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2). Its specificity has been confirmed using a panel of 31 other kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 > 200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated synovial fibroblasts RASF. A 25 mM (1 mg/178 µl) solution of IKK-2 Inhibitor, SC-514 (Cat. No. 401485) in DMSO is also available.
Catalogue Number401479
Brand Family Calbiochem®
SynonymsSC-514
References
ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
Product Information
CAS number354812-17-2
ATP CompetitiveY
FormPale yellow solid
Hill FormulaC₉H₈N₂OS₂
Chemical formulaC₉H₈N₂OS₂
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetIKK-2
Primary Target IC<sub>50</sub>3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

IKK-2 Inhibitor, SC-514 - CAS 354812-17-2 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
401479

Riferimenti bibliografici

Panoramica delle referenze
Baxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision12-April-2011 RFH
SynonymsSC-514
DescriptionA cell-permeable, potent, reversible, ATP-competitive and highly selective inhibitor of IKK-2 (IC50 ~3-12 µM for IKK-2 homodimer, IKK-1/IKK-2 heterodimer, and IKK-2) that also displays anti-inflammatory properties. Specificity has been reported using a panel of 31 additional kinases, including IKK isoforms IKK-1, IKK-i, and TBK-1 (IC50 >200 µM). Shown to specifically block NF-κB-dependent gene expression, but not MAP kinase pathways, in stimulated RASF synovial fibroblast cells. Does not inhibit the phosphorylation and activation of the IKK complex.
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number354812-17-2
Chemical formulaC₉H₈N₂OS₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (20 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesBaxter, A., et al. 2004 Bioorg. Med. Chem. Lett. 14, 2817.
Kishore, N., et al. 2003. J. Biol. Chem. 278, 32861.