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420145 JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem

420145
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
796041-65-1C₂₃H₂₀ClN₃O

Products

Numero di catalogoConfezionamento Qtà/conf
420145-25MG 25 mg
Description
OverviewA cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit the kinase activity of JAK3 (by 81% and 36% at 90 and 30 µM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 µM, respectively) and reduce JAK1/3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. Reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC50 = 17 and 25 µM, respectively) in vitro and be efficacious in ameliorating delayed hypersensitivity reaction in mice (by ~78% with a daily oral dose of 50 mg/kg) and in prolonging the survival of heart transplant-recipient rats (by >3-fold with 60 mg/kg/day, p.o.) in vivo.
Catalogue Number420145
Brand Family Calbiochem®
SynonymsN-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
References
ReferencesCarbonnelle, D., et al. 2009. J. Pharm. Exp. Ther. 331, 710.
Carbonnelle, D., et al. 2007. Eur. J. Med. Chem. 42, 686.
Product Information
CAS number796041-65-1
FormWhite solid
Hill FormulaC₂₃H₂₀ClN₃O
Chemical formulaC₂₃H₂₀ClN₃O
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special Instructionsfollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

JAK3 Inhibitor VII, AD412 - CAS 796041-65-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
420145

Riferimenti bibliografici

Panoramica delle referenze
Carbonnelle, D., et al. 2009. J. Pharm. Exp. Ther. 331, 710.
Carbonnelle, D., et al. 2007. Eur. J. Med. Chem. 42, 686.

Informazioni tecniche

Titolo
JAK/STAT Signaling Research Focus
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
SynonymsN-(Pyridin-4-yl)-3-[1-(4-chlorobenzyl)indol-3-yl]-propanamide
DescriptionA cell-permeable indole-3-propanamide immunosuppressant that is shown to selectively inhibit the kinase activity of JAK3 (by 81% and 36% at 90 and 30 µM, respectively) over that of JAK2 (by 29% and 0% at 90 and 30 µM, respectively) and reduce JAK1/3-dependent phosphorylations of Akt, STAT5a/b, and Erk1/2 in IL-2-stimulated CTL-L2 cells, but not JAK1/2-dependent STAT1 phosphorylation in INF-γ-stimulated U266 cultures. Reported to inhibit ConA-stimulated murine splenocytes and PHA-stimulated human PBL proliferation (IC50 = 17 and 25 µM, respectively) in vitro and be efficacious in ameliorating delayed hypersensitivity reaction in mice (by ~78% with a daily oral dose of 50 mg/kg) and in prolonging the survival of heart transplant-recipient rats (by >3-fold with 60 mg/kg/day, p.o.) in vivo.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number796041-65-1
Chemical formulaC₂₃H₂₀ClN₃O
Purity≥95% by HPLC
SolubilityDMSO (100 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special Instructionsfollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesCarbonnelle, D., et al. 2009. J. Pharm. Exp. Ther. 331, 710.
Carbonnelle, D., et al. 2007. Eur. J. Med. Chem. 42, 686.