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420123 JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem

420123
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₁₅H₁₀N₂O 54642-23-8

Products

Numero di catalogoConfezionamento Qtà/conf
420123-1MG Fiala di plastica 1 mg
Description
OverviewA useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119). Inhibits JNK2 and JNK3 only at much higher concentrations (IC50 = 18 µM and 24 µM, respectively) compared to SP600125 (IC50 = 40 nM and 90 nM, respectively).
Catalogue Number420123
Brand Family Calbiochem®
SynonymsN¹-Methyl-1,9-pyrazoloanthrone
References
ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
Product Information
CAS number54642-23-8
ATP CompetitiveY
FormYellow solid
Hill FormulaC₁₅H₁₀N₂O
Chemical formulaC₁₅H₁₀N₂O
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetA useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119)
Primary Target IC<sub>50</sub>18 µM and 24 µM against JNK2 and JNK3, respectively
Purity≥97% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

JNK Inhibitor II, Negative Control - CAS 54642-23-8 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
420123

Riferimenti bibliografici

Panoramica delle referenze
Shin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.

Citazioni

Titolo
  • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.
  • Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision13-April-2011 RFH
    SynonymsN¹-Methyl-1,9-pyrazoloanthrone
    DescriptionA useful negative control for JNK Inhibitor II (SP600125, Cat. No. 420119). Inhibits JNK2 and JNK3 only at much higher concentrations (IC50 = 18 µM and 24 µM, respectively) compared to SP600125 (IC50 = 40 nM and 90 nM, respectively).
    FormYellow solid
    Intert gas (Yes/No) Packaged under inert gas
    CAS number54642-23-8
    Chemical formulaC₁₅H₁₀N₂O
    Structure formulaStructure formula
    Purity≥97% by HPLC
    SolubilityDMSO (10 mg/ml)
    Storage -20°C
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable up to 3 months at -20°C.
    Toxicity Standard Handling
    ReferencesShin, M., and Boyd, Y.D. 2002. Biochim. Biophys. Acta 1589, 311.
    Bennett, B.L., et al. 2001. Proc. Natl. Acad. Sci. USA 98, 13681.
    Citation
  • Alexandra Thiel, Mira Heinonen, Johanna Rintahaka, Tuija Hallikainen, and Annabrita Hemmes, Dan A. Dixon, Caj Haglund, and Ari Ristimaki. (2006) EXPRESSION OF CYCLOOXYGENASE-2 IS REGULATED BY GSK-3 IN GASTRIC CANCER CELLS. Journal of Biological Chemistry in press,.