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420129 JNK Inhibitor V - CAS 345987-15-7 - Calbiochem

420129
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Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₂₀H₁₆N₆S 345987-15-7

Products

Numero di catalogoConfezionamento Qtà/conf
420129-5MG Fiala di plastica 5 mg
Description
OverviewA cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
Catalogue Number420129
Brand Family Calbiochem®
SynonymsSAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
References
ReferencesGaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.
Product Information
CAS number345987-15-7
ATP CompetitiveY
FormYellow solid
Hill FormulaC₂₀H₁₆N₆S
Chemical formulaC₂₀H₁₆N₆S
Hygroscopic Hygroscopic
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Application CommentsSoluble in DMSO, aliquot & store at -20*C; stable for 3 months
Biological Information
Primary TargethJNK 1, hJNK 2, hJNK 3
Primary Target IC<sub>50</sub>150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively
Purity≥95% by HPLC (sum of two isomers)
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Harmful
Storage -20°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

JNK Inhibitor V - CAS 345987-15-7 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

JNK Inhibitor V - CAS 345987-15-7 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
420129

Riferimenti bibliografici

Panoramica delle referenze
Gaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision04-January-2010 RFH
SynonymsSAPK Inhibitor V, 1,3-Benzothiazol-2-yl-(2-((2-(3-pyridinyl)ethyl)amino)-4-pyrimidinyl)acetonitrile, AS601245
DescriptionA cell-permeable pyrimidinyl compound that displays anti-inflammatory properties. Acts as a potent, reversible, and ATP-competitive inhibitor of c-Jun N-terminal kinase (JNK, IC50 = 150, 220, and 70 nM for hJNK1, hJNK2, and hJNK3, respectively) with a 10- to 100-fold greater selectivity over a panel of 25 other commonly studied kinases (IC50 typically in the range of 1-10 µM or no effect at 10 µM). Its in vivo efficacy has been demonstrated in gerbils, mice, and rats via oral, i.v., or i.p. administration.
FormYellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number345987-15-7
Chemical formulaC₂₀H₁₆N₆S
Structure formulaStructure formula
Purity≥95% by HPLC (sum of two isomers)
SolubilityDMSO (10 mg/ml)
CommentsSoluble in DMSO, aliquot & store at -20*C; stable for 3 months
Storage -20°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Harmful
ReferencesGaillard, P., et al. 2005. J. Med. Chem. 48, 4596.
Carboni, S., et al. 2005. J. Neurochem. 92, 1054.
Ferrandi, C., et al. 2004. Br. J. Pharmacol. 142, 953.
Carboni, S., et al. 2004. J. Pharm. Exp. Ther. 310, 25.