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420133 JNK Inhibitor VI, TI-JIP153-163 - Calbiochem

420133
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₆₁H₁₀₄N₂₀O₁₄

Products

Numero di catalogoConfezionamento Qtà/conf
420133-2MG Fiala di plastica 2 mg
Description
OverviewA murine JIP-1 JNK-binding domain- (JBD) derived 11-mer peptide that directly interacts with JNK (KD in low µM range) and specifically inhibits JNK kinase activity without inhibitory effects towards ERK or p38. The inhibition is not limited only to JBD-containing substrates and is found to be mixed/non-competitive with respect to ATP. JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, is also available (Cat. No. 420134).
Catalogue Number420133
Brand Family Calbiochem®
SynonymsTruncated Inhibitor based on JNK-Interacting Protein 1, H₂N-RPKRPTTLNLF-NH₂
References
ReferencesBarr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
Product Information
ATP CompetitiveN
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Hill FormulaC₆₁H₁₀₄N₂₀O₁₄
Chemical formulaC₆₁H₁₀₄N₂₀O₁₄
Hygroscopic Hygroscopic
ReversibleN
Quality LevelMQ100
Applications
Biological Information
Primary TargetJNK
Primary Target IC<sub>50</sub>KD in low µM range
Purity≥97% by HPLC
Physicochemical Information
Cell permeableN
Peptide SequenceH-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Hygroscopic Hygroscopic
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

JNK Inhibitor VI, TI-JIP153-163 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

JNK Inhibitor VI, TI-JIP153-163 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
420133

Riferimenti bibliografici

Panoramica delle referenze
Barr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision25-July-2008 RFH
SynonymsTruncated Inhibitor based on JNK-Interacting Protein 1, H₂N-RPKRPTTLNLF-NH₂
DescriptionA murine JIP-1 JNK-binding domain- (JBD) derived 11-mer peptide that directly interacts with JNK (KD in low µM range) and specifically inhibits JNK kinase activity without inhibitory effects towards ERK or p38. The inhibition is not limited only to JBD-containing substrates and is found to be mixed/non-competitive with respect to ATP. JNK Inhibitor VII, TAT-TI-JIP153-163, Cell-Permeable, is also available (Cat. No. 420134).
FormLyophilized
FormulationSupplied as a trifluoroacetate salt.
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₆₁H₁₀₄N₂₀O₁₄
Peptide SequenceH-Arg-Pro-Lys-Arg-Pro-Thr-Thr-Leu-Asn-Leu-Phe-NH₂
Purity≥97% by HPLC
SolubilityDMSO (5 mg/ml) or H₂O (1 mg/ml)
Storage +2°C to +8°C
Hygroscopic
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesBarr, R.K., et al. 2004. J. Biol. Chem. 279, 36327.
Barr, R.K., et al. 2002. J. Biol. Chem. 277, 10987.