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420298 K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem

420298
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical FormulaCAS #
C₂₇H₂₁N₃O₅ 97161-97-2

Products

Numero di catalogoConfezionamento Qtà/conf
420298-100UG Fiala di plastica 100 μg
Description
OverviewA cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297).
Catalogue Number420298
Brand Family Calbiochem®
References
ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
Tapley, P., et al. 1992. Oncogene 7, 371.
Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
Product Information
CAS number97161-97-2
ATP CompetitiveY
FormWhite solid
Hill FormulaC₂₇H₂₁N₃O₅
Chemical formulaC₂₇H₂₁N₃O₅
ReversibleY
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
ApplicationK-252a, Nocardiopsis sp., CAS 97161-97-2, is a cell-permeable, ATP-competitive inhibitor of multiple protein kinases (Ki = 1.8, 20, 18, 25, 20, 3 nM for CaMKII, MLCK, PKA, PKC, PKG & 140 trk).
Biological Information
Primary TargetCaM kinase II
Primary Target K<sub>i</sub>1.8 nM, 20 nM, 18 nM, 25 nM, 20 nM, 3 nM, against CaM kinase II, myosin light chain kinase, protein kinase A, protein kinase C, protein kinase G, NGF receptor gp140trk, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
RTECSNZ0550000
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage -20°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Transport Information
Supplemental Information
Specifications

Documentation

K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

K-252a, Nocardiopsis sp. - CAS 97161-97-2 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
420298

Riferimenti bibliografici

Panoramica delle referenze
Cools, J., et al. 2004. Cancer Res. 64, 6385.
Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
Tapley, P., et al. 1992. Oncogene 7, 371.
Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.

Citazioni

Titolo
  • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
  • Scheda tecnica

    Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

    Revision25-November-2009 RFH
    DescriptionA cell-permeable, reversible, and ATP-competitive inhibitor against multiple protein kinases, including, but not limited to, CaM kinase II (Ki = 1.8 nM), myosin light chain kinase (Ki = 20 nM), protein kinase A (Ki = 18 nM), protein kinase C (Ki = 25 nM), protein kinase G (Ki = 20 nM), NGF receptor gp140trk (IC50 = 3 nM), its transforming trk oncogenes, and the related neurotrophin receptors gp145trkB and gp145trkC. Reported to induce apoptosis and cell cycle arrest by decreasing Cdk1 and Cdc25c activity in T98G cells and inhibit Flt3 phosphorylation in Flt3/Itd-BaF3 cells (IC50 <50 nM). Also available as a premade 1 mM (100 µg/214 µl) solution in DMSO (Cat. No. 420297).
    FormWhite solid
    CAS number97161-97-2
    RTECSNZ0550000
    Chemical formulaC₂₇H₂₁N₃O₅
    Structure formulaStructure formula
    Purity≥95% by HPLC
    SolubilityDMF or DMSO (1 mg/ml)
    Storage -20°C
    Protect from light
    Do Not Freeze Ok to freeze
    Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
    Toxicity Standard Handling
    ReferencesCools, J., et al. 2004. Cancer Res. 64, 6385.
    Chin, L.S., et al. 1999. Cancer Invest. 17, 391.
    Tapley, P., et al. 1992. Oncogene 7, 371.
    Hashimoto, Y. 1991. Biochem. Biophys. Res. Commun. 181, 423.
    Nakanishi, S. 1988. J. Biol. Chem. 263, 6215.
    Kase, H., et al. 1987. Biochem. Biophys. Res. Commun. 142, 436.
    Citation
  • Huanyu Dou, et al. (2005) Neuroprotective mechanisms of lithium in murine human immunodeficiency virus-1 encephalitis. Journal of Neuroscience 25, 8375-8385.
  • Prodotti e applicazioni correlate

    Categorie

    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Calmodulin-Dependent Protein Kinase (CaM Kinase) Inhibitors
    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase G (PKG; cGMP-Dependent Protein Kinase) Inhibitors
    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Myosin Light Chain Kinase (MLCK) Inhibitors
    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase A (PKA; cAMP-Dependent Protein Kinase) Inhibitors
    Life Science Research > Inhibitors and Biochemicals > Small Molecules & Inhibitors > Protein Phosphorylation / Dephosphorylation > Protein Kinase C (PKC) Inhibitors