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434610 Leukadherin-1 - Calbiochem

434610
Purchase on Sigma-Aldrich

Panoramica

Replacement Information

Tabella delle specifiche principali

Empirical Formula
C₂₂H₁₅NO₄S₂

Products

Numero di catalogoConfezionamento Qtà/conf
434610-25MG Bottiglia di vetro 25 mg
Description
OverviewA furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models involving mice, rats, and zebrafish embryos in vivo.
Catalogue Number434610
Brand Family Calbiochem®
SynonymsLA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, αMβ2 Agonist II, CD11b Agonist II
References
ReferencesMaiguel, D., et al. 2011. Sci. Signal. 4, ra57.
Product Information
FormRed-brown solid
Hill FormulaC₂₂H₁₅NO₄S₂
Chemical formulaC₂₂H₁₅NO₄S₂
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Purity≥95% by HPLC
Physicochemical Information
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Standard Handling
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

Leukadherin-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

Leukadherin-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
434610

Riferimenti bibliografici

Panoramica delle referenze
Maiguel, D., et al. 2011. Sci. Signal. 4, ra57.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision03-May-2012 JSW
SynonymsLA1, Mac-1 Agonist II, CR3 Agonist II, CD11b/CD18 Agonist, 4-(5-((3-Benzyl-4-oxo-2-thioxo-1,3-thiazolidin-5-ylidene)methyl)furan-2-yl)-benzoic acid, αMβ2 Agonist II, CD11b Agonist II
DescriptionA furanyl thiazolidinone compound that binds CD11b αA/αI domain in a reversible manner and stabilizes αA in a high-affinity binding conformation toward known CD11b/CD18 (αMβ2; CR3; Mac-1) ligands, fibrinogen, ICAM-1, and iC3B. Reported to be superior to IMB-10 (Cat. No. 407271) in enhancing Mac-1-mediated cell adhesion (EC50 = 4 vs. >50 µM on fibrinogen surface). Effectively suppresses leukocyte recruitment in various inflammatory disease models in vivo, including thioglycolate-induced peritonitis (10 nmol/0.2 ml/mouse; i.v.), anti-GBM-induced nephritis (25 nmol/0.5 ml/mouse; i.p.), balloon-induced artery injury (50 nmol/1 ml/rat; i.m.), and zebrafish tailfin injury.CR3
FormRed-brown solid
Intert gas (Yes/No) Packaged under inert gas
Chemical formulaC₂₂H₁₅NO₄S₂
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (5 mg/ml; yellow solution)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Standard Handling
ReferencesMaiguel, D., et al. 2011. Sci. Signal. 4, ra57.