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444144 MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem

444144
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
6964-62-1C₂₃H₂₀N₂O

Products

Numero di catalogoConfezionamento Qtà/conf
444144-10MG Fiala di plastica 10 mg
Description
OverviewA cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (Ki = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.
Catalogue Number444144
Brand Family Calbiochem®
Synonyms7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II
References
ReferencesLu, Y., et al. 2006. J. Med. Chem. 49, 3759.
Product Information
CAS number6964-62-1
ATP CompetitiveN
FormWhite solid
Hill FormulaC₂₃H₂₀N₂O
Chemical formulaC₂₃H₂₀N₂O
ReversibleN
Structure formula ImageStructure formula Image
Applications
Biological Information
Primary TargetMDM2
Primary Target K<sub>i</sub>120 nM against MDM2
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Irritant
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

MDM2 Antagonist II, NSC 66811 - CAS 6964-62-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
444144

Riferimenti bibliografici

Panoramica delle referenze
Lu, Y., et al. 2006. J. Med. Chem. 49, 3759.
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision13-April-2011 RFH
Synonyms7-(Anilino(phenyl)-methyl)-2-methyl-8-quinolinol, MDM2 Inhibitor II
DescriptionA cell-permeable, non-peptidyl, quinolinol compound that binds MDM2 with high affinity (Ki = 120 nM) and disrupts MDM2-p53 interaction. Shown to dose-dependently induce cellular accumulation of p53, MDM2, and p21 in HCT-116 human colon cancer cell line with wild-type p53.
FormWhite solid
Intert gas (Yes/No) Packaged under inert gas
CAS number6964-62-1
Chemical formulaC₂₃H₂₀N₂O
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution, aliquot and freeze (-20°C). Stock solutions are stable for up to 6 months at -20°C.
Toxicity Irritant
ReferencesLu, Y., et al. 2006. J. Med. Chem. 49, 3759.