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444145 MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem

444145
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Panoramica

Replacement Information

Tabella delle specifiche principali

CAS #Empirical Formula
562823-84-1C₁₅H₁₂BIO₃

Products

Numero di catalogoConfezionamento Qtà/conf
444145-10MG Fiala di plastica 10 mg
Description
OverviewA cell-permeable boranyl-chalcone that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex. Exhibits selective toxicity towards MDM2 overexpressing human breast cancer cell lines (IC50 = 10, 8.8, and 7 µM for MDA-MB-435, MDA-MB-231, and Wt-MCF7, respectively) compared to normal breast cell lines (IC50 = 75 and 63 µM for MCF-10A and MCF-12A, respectively).
Catalogue Number444145
Brand Family Calbiochem®
Synonymstrans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV
References
ReferencesKumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.
Product Information
CAS number562823-84-1
ATP CompetitiveN
FormPale yellow solid
Hill FormulaC₁₅H₁₂BIO₃
Chemical formulaC₁₅H₁₂BIO₃
ReversibleN
Structure formula ImageStructure formula Image
Quality LevelMQ100
Applications
Biological Information
Primary TargetMDM2
Primary Target IC<sub>50</sub>10, 8.8, and 7 µM in selective toxicity for MDA-MB-435, MDA-MB-231, and Wt-MCF7, respectively
Purity≥95% by HPLC
Physicochemical Information
Cell permeableY
Dimensions
Materials Information
Toxicological Information
Safety Information according to GHS
Safety Information
Product Usage Statements
Storage and Shipping Information
Ship Code Ambient Temperature Only
Toxicity Carcinogenic / Teratogenic
Storage +2°C to +8°C
Protect from Light Protect from light
Do not freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Packaging Information
Packaged under inert gas Packaged under inert gas
Transport Information
Supplemental Information
Specifications

Documentation

MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem MSDS

Titolo

Scheda di sicurezza (MSDS) 

MDM2 Inhibitor - CAS 562823-84-1 - Calbiochem Certificati d'Analisi

TitoloNumero di lotto
444145

Riferimenti bibliografici

Panoramica delle referenze
Kumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.

Brochure

Titolo
Interactive Pathway Calendar
Scheda tecnica

Note that this data sheet is not lot-specific and is representative of the current specifications for this product. Please consult the vial label and the certificate of analysis for information on specific lots. Also note that shipping conditions may differ from storage conditions.

Revision19-February-2008 JSW
Synonymstrans-4-Iodo, 4ʹ-boranyl-chalcone, MDM2 Antagonist IV
DescriptionA cell-permeable boranyl-chalcone compound that binds strongly to MDM2 and irreversibly disrupts MDM2/p53 protein complex formation. Exhibits selective toxicity to MDM2-overexpressing human breast cancer cell lines (IC50 = 10 µM for MDA-MB-435, 8.8 µM for MDA-MB-231, and 7 µM for Wt-MCF7) compared to normal breast cell lines (IC50 = 75 µM for MCF-10A and 63 µM for MCF-12A).
FormPale yellow solid
Intert gas (Yes/No) Packaged under inert gas
CAS number562823-84-1
Chemical formulaC₁₅H₁₂BIO₃
Structure formulaStructure formula
Purity≥95% by HPLC
SolubilityDMSO (10 mg/ml)
Storage +2°C to +8°C
Protect from light
Do Not Freeze Ok to freeze
Special InstructionsFollowing reconstitution aliquot and freeze (-20°C). Stock solutions are stable for up to 3 months at -20°C.
Toxicity Carcinogenic / Teratogenic
ReferencesKumar, S.K., et al. 2003. J. Med. Chem. 46, 2813.